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Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives

Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives

Beezer, A.E., King, A.S.H., Martin, I.K., Mitchell, J.C. ORCID: 0000-0003-2945-3292, Twyman, L.J. and Wain, C.F. (2003) Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives. Tetrahedron, 59 (22). pp. 3873-3880. ISSN 0040-4020 (Online)

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Abstract

This paper describes the synthesis of three neutral water soluble poly(amidoamine) (PAMAM) dendrimer derivatives. The ability of the two larger dendrimers to bind small acidic hydrophobic molecules is reported. Spectroscopic data and pH behaviour suggested that the acidic hydrophobes were forming stable ion pairs with the dendrimer's internal, basic tertiary nitrogens. With respect to forming 1:1 and 2:1 substrate/dendrimer complexes, both of the larger dendrimers were equally efficient at binding. All dendrimer/substrate complexes were completely miscible with water in all proportions (i.e. infinitely water soluble). When the bound substrates are drug moieties, then the resulting complexes could be considered as potential drug delivery systems. Flow calorimetry demonstrated that the dendrimers were able to release their hydrophobic guests when in contact with a biological cell.

Item Type: Article
Additional Information: [1] On the article J. C. Mitchell's is spelt as "J. C. Mitchel". [2] Financial support from the EPSRC, BBSRC, Royal Society (small equipment grant) and the University of Sheffield are gratefully acknowledged.
Uncontrolled Keywords: dendrimers, drug carriers
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Pre-2014 Departments: School of Science
School of Science > Medway Sciences Research Group
Related URLs:
Last Modified: 14 Oct 2016 09:10
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4152

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