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Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa

Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa

Ayensu, Isaac, Mitchell, John and Boateng, Joshua (2010) Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1273-1274. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)

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Abstract

The buccal mucosa has received increased attention in recent years for the delivery of proteins/peptides as an alternative to the currently used parenteral route [1]. Although limited by molecular size, hydrophobicity and low permeability of membranes, thiolated chitosan derivatives have however been identified to deliver proteins/peptides across the buccal mucosa because of their mucoadhesive, penetration enhancing and peptidase inhibition properties [2]. This project aims to develop freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa and to determine the effectiveness of cryoprotection and annealing on the stability of the protein drug.

Item Type: Article
Additional Information: [1] This is an abstract from a paper given at UK Pharmsci 2010 The Science of Medicines held at The East Midlands Conference Center, Nottingham, 1-3 September 2010. [2] This abstract is published in the Journal of Pharmacy and Pharmacology, Special Issue: UK-PharmSci 2010 - The Science of Medicines. Abstracts from the UK conference, 1-3 September, Volume 62, Issue 10, pages 1201–1516, October 2010. [3] First published online: 3 September 2010.
Uncontrolled Keywords: chitosan, drug-delivery, mucoadhesive, freeze-drying, wafers, thiolated chitosan
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:10
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/4151

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