Knipholone anthrone from kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells
Habtemariam, S. (2010) Knipholone anthrone from kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells. Fitoterapia, 81 (8). pp. 1013-1019. ISSN 0367-326X (doi:10.1016/j.fitote.2010.06.021)Full text not available from this repository.
The present study examines the comparative cytotoxicity of knipholone (KP) and knipholone anthrone (KA) in leukameic and melonocyte cancer cell lines. It was found that KA induces a rapid onset of cytotoxicity with IC50 values ranging from 0.5 - 3.3 mM. In comparison to KA, KP was 70-480-times less toxic to cancer cells. Morphological and biochemical studies revealed that the cytotoxicity of KA was coupled with a quick loss of membrane integrity leading to necrotic cell death. The study identified KA as a new class of natural potential anticancer agent with a wide range of toxicological and pharmacological implications.
|Uncontrolled Keywords:||Kniphofia foliosa (Asphodelaceae), Knipholone, Knipholone anthrone, cytotoxicity, apoptosis, necrosis|
|Subjects:||Q Science > Q Science (General)
Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
|Faculty / Department / Research Groups:||Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences|
|Last Modified:||07 Dec 2016 16:55|
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