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Liquisolid compacts: the effect of cosolvent and HPMC on theophylline release

Liquisolid compacts: the effect of cosolvent and HPMC on theophylline release

Nokhodchi, Ali, Aliakbar, Roya, Desai, Sandipkumar and Javadzadeh, Yousef (2010) Liquisolid compacts: the effect of cosolvent and HPMC on theophylline release. Colloids and Surfaces B: Biointerfaces, 79 (1). pp. 262-269. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2010.04.008)

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Abstract

Liquisolid technique as an approach was developed to sustain the drug release from matrix compacts.

Liquisolid tablets were prepared by mixing liquid medication with silica–Eudragit RL or RS followed by the compaction of the mixture. For comparison purposes physical mixtures of all ingredients were prepared. The effect of the type of liquid medication and HPMC concentration on drug release was investigated. The interaction between excipients and theophylline was investigated by differential scanning calorimetry. Comparison study of physicomechnanical properties of liquisolid tablets with conventional tablets showed that most of liquisolid formulations had superior flowability and compactibility in comparison with physical mixtures. The results suggested that the presence of non-volatile cosolvent is vital to produce slow release pattern for some of liquisolid compacts. The type of cosolvent had significant effect on drug release and it was revealed that by changing the type of cosolvent the desirable release profile is achievable. The sustained release action of HPMC was enhanced in liquisolid compacts in comparison to simple sustained release matrix tablets. It was shown that liquisolid compacts has a potential to produce zero-order release kinetics for less water soluble drugs such as theophylline.

Item Type: Article
Additional Information: [1] Available online 21 April 2010. [2] This journal was formerly part of Colloids and Surfaces.
Uncontrolled Keywords: liquisolid compacts, eudragit, drug release, HPMC, tablet breaking force, dissolution parameters
Subjects: R Medicine > RS Pharmacy and materia medica
Pre-2014 Departments: School of Science
School of Science > Department of Medway Sciences
Related URLs:
Last Modified: 14 Oct 2016 09:09
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/3509

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