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Evaluation of air induced segregation tendencies in pharmaceutical blends using a bench scale tester

Evaluation of air induced segregation tendencies in pharmaceutical blends using a bench scale tester

Bradley, Michael S.A., Farnish, Richard J., Reed, Alan R. and Kulkarni, Prasanna (2007) Evaluation of air induced segregation tendencies in pharmaceutical blends using a bench scale tester. In: 9th International Conference on Bulk Materials Storage, Handling and Transportation, 9-11 October 2007, The University of Newcastle, N.S.W, Australia.. (Unpublished)

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Abstract

Summary Segregation is a complex mechanism that leads to separation of various particulate fractions in bulk
solids. The nucleation and acceleration of segregation can potentially happen at various stages in the process or
handling of a given bulk particulate.
Any bulk solid composed of particulates under 50μm size range and exhibiting variations in particle
characteristics can be susceptible to air induced segregation. The pharmaceutical sector uses many types of dry powders exhibiting these characteristics in various manufacturing processes and products.
The presented work was undertaken to evaluate the susceptibility of an exemplar pharmaceutical blend to
segregate under the influence of counter current air-flow using a bench size tester. The results of the segregation
tests have then been used to predict the variation in the fine particles (often active content) of the bulk
particulate. The techniques for minimising segregation are largely dependent on establishing the most dominant mode
governing the segregation mechanism (in particular process and handling conditions). The air induced segregation tester has been shown to be a useful and reliable tool for predicting the propensity of fine powder blends to be susceptible to counter air current segregation, while the QPM segregation tester has been proven to
indicate the propensity for surface segregation

Item Type: Conference or Conference Paper (Paper)
Uncontrolled Keywords: bulk solids, segregation
Subjects: T Technology > T Technology (General)
T Technology > TP Chemical technology
T Technology > TS Manufactures
Faculty / Department / Research Group: Faculty of Engineering & Science > Wolfson Centre for Bulk Solids Handling Technology
Related URLs:
Last Modified: 17 Oct 2016 10:03
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2911

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