Skip navigation

Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces

Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces

Boateng, Joshua S. ORCID: 0000-0002-6310-729X, Stevens, Howard N.E., Eccleston, Gillian M., Auffret, Anthony D., Humphrey, Michael J. and Matthews, Kerr H. (2009) Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug Development and Industrial Pharmacy, 35 (8). pp. 986-996. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.1080/03639040902744704)

Full text not available from this repository.

Abstract

Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air. Three methods, (a) passive hydration, (b) vortex hydration with heating, and (c) cold hydration, were investigated to determine the most effective means of preparing gels for each of the three polymers. Different drying conditions [relative humidity - RH (6-52%) and temperature (3-45 degrees C)] were investigated to determine the effect of drying rate on the films prepared by drying the polymeric gels. The tensile properties of the CMC films were determined by stretching dumbbell-shaped films to breaking point, using a Texture Analyser. Glycerol was used as a plasticizer, and its effects on the drying rate, physical appearance, and tensile properties of the resulting films were investigated. Vortex hydration with heating was the method of choice for preparing gels of SA and CMC, and cold hydration for xanthan gels. Drying rates increased with low glycerol content, high temperature, and low relative humidity. The residual water content of the films increased with increasing glycerol content and high relative humidity and decreased at higher temperatures. Generally, temperature affected the drying rate to a greater extent than relative humidity. Glycerol significantly affected the toughness (increased) and rigidity (decreased) of CMC films. CMC films prepared at 45 degrees C and 6% RH produced suitable films at the fastest rate while films containing equal quantities of glycerol and CMC possessed an ideal balance between flexibility and rigidity.

Item Type: Article
Additional Information: [1] Published in August 2009. [2] Published in Drug Development and Industrial Pharmacy 2009 35:8, 986-996.
Uncontrolled Keywords: Carboxymethylcellulose; Drying rate; Films; Mechanical properties; Plasticizer; Tensile testing
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 07 Dec 2016 10:32
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2778

Actions (login required)

View Item View Item