The implementation of FT-Raman spectroscopy to study solid state moisture induced changes in the crystallographic nature of pharmaceutical excipients - a lesson in humidity
Major, P.J., Cornelius, V.J., Mitchell, J.C. and Murphy, J. (2007) The implementation of FT-Raman spectroscopy to study solid state moisture induced changes in the crystallographic nature of pharmaceutical excipients - a lesson in humidity. Journal of Pharmacy and Pharmacology, 59 (S1). A38-A38. ISSN 0022-3573 (doi:10.1211/002235707781849999)Full text not available from this repository.
An aqueous solution of sucrose was lyophilised, producing amorphous sucrose. This wasthen stored under different humidity at 25ºC for 1 week, allowing some samples tocrystallise. FT-Raman spectroscopy and PXRD have been successfully shown toqualitatively distinguish between amorphous and crystalline samples of sucrose. The datafrom the two techniques is complementary.
|Additional Information:|| Presented at BPC 2007, 10-12 Sep 2007, Manchester, UK. Meeting Abstract 99.  This article (no. 99) was published in Supplement 1, of the Journal of Pharmacy and Pharmacology 2007, 59, Special Issue: BPC Science Abstracts.|
|Uncontrolled Keywords:||FT-Raman, PXRD, sucrose, humidity, amorphous, crystalline|
|Subjects:||Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
|School / Department / Research Groups:||School of Science
Faculty of Engineering & Science > School of Science
School of Science > Department of Medway Sciences
Faculty of Engineering & Science > School of Science > Department of Medway Sciences
|Last Modified:||27 Nov 2012 09:53|
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