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The implementation of FT-Raman spectroscopy to study solid state moisture induced changes in the crystallographic nature of pharmaceutical excipients - a lesson in humidity

The implementation of FT-Raman spectroscopy to study solid state moisture induced changes in the crystallographic nature of pharmaceutical excipients - a lesson in humidity

Major, P.J., Cornelius, V.J., Mitchell, J.C. and Murphy, J. (2007) The implementation of FT-Raman spectroscopy to study solid state moisture induced changes in the crystallographic nature of pharmaceutical excipients - a lesson in humidity. Journal of Pharmacy and Pharmacology, 59 (S1). A38-A38. ISSN 0022-3573 (doi:10.1211/002235707781849999)

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Abstract

An aqueous solution of sucrose was lyophilised, producing amorphous sucrose. This wasthen stored under different humidity at 25ºC for 1 week, allowing some samples tocrystallise. FT-Raman spectroscopy and PXRD have been successfully shown toqualitatively distinguish between amorphous and crystalline samples of sucrose. The datafrom the two techniques is complementary.

Item Type: Article
Additional Information: [1] Presented at BPC 2007, 10-12 Sep 2007, Manchester, UK. Meeting Abstract 99. [2] This article (no. 99) was published in Supplement 1, of the Journal of Pharmacy and Pharmacology 2007, 59, Special Issue: BPC Science Abstracts.
Uncontrolled Keywords: FT-Raman, PXRD, sucrose, humidity, amorphous, crystalline
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Pre-2014 Departments: School of Science
School of Science > Department of Medway Sciences
Related URLs:
Last Modified: 14 Oct 2016 09:06
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2521

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