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Epilobium parviflorum Schreb. - in vitro study of biological action

Epilobium parviflorum Schreb. - in vitro study of biological action

Hevesi Tóth, Barbara, Houghton, P.J., Habtemariam, S., Milligan, S., Kalita, C.J., Purohit, A. and Kéry, Á. (2007) Epilobium parviflorum Schreb. - in vitro study of biological action. Planta Medica, 73 (9). P454. ISSN 0032-0943 (doi:10.1055/s-2007-987234)

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Abstract

Epilobium parviflorum Schreb. (Onagraceae) is used for the treatment of benign prostatic hyperplasia (BPH), which is regarded as an endocrine disorder caused by age-related hormone imbalance and increased oxidative damage [1,2,3]. Epilobium can moderate the obstructive and the irritative symptoms of BPH [1] but its biological action is not entirely identified. E. parviflorum is rich in phytosterols, flavonoids (myricetin, quercetin, kaempferol and their glycosides), phenolic acids, catechins, ellagi- and gallotannins [4]. The potential biological effects of Epilobium parviflorum Schreb. have been investigated, in respect to its antioxidant, anti-inflammatory, enzyme-inhibitory and anti-androgenic effect. The whole-plant water extract showed higher antioxidant effect (IC50=1.65±0.05µg/mL) in DPPH assay than Trolox or ascorbic acid and inhibited the lipid peroxidation examined in TBA assay (IC50=2.31±0.18mg/mL). In concentrations 0.20-15.00µg/mL the extract possessed a protective effect comparable to catalase enzyme (2500 IU/mL), against oxidative damage generated on fibroblast cells. The examination of the COX-inhibitory effect showed that E. parviflorum had an anti-inflammatory effect (IC50=1.38±0.08µg/mL). Investigation of steroid receptor binding ability and the aromatase enzyme-inhibition showed negative results in the concentration range examined.

Item Type: Article
Additional Information: Abstract for poster presented at 55th Annual Congress of the Society-for-Medicinal-Plant-ResearchSEP 02-06, 2007 Karl Franzens Univ, Graz, Austria
Uncontrolled Keywords: Epilobium parviflorum Schreb, benign prostatic hyperplasia, BPH
Subjects: R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 09 Dec 2016 15:49
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2510

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