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A preliminary investigation of the in vitro bioactivity of white Portland cement

A preliminary investigation of the in vitro bioactivity of white Portland cement

Coleman, Nichola J., Nicholson, John W. and Awosanya, Kunle (2007) A preliminary investigation of the in vitro bioactivity of white Portland cement. Cement and Concrete Research, 37 (11). pp. 1518-1523. ISSN 0008-8846 (doi:10.1016/j.cemconres.2007.08.008)

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Abstract

Freshly-mixed and partially-cured ordinary Portland cement (OPC) pastes have been shown to exhibit good biological compatibility with a range of cells and tissue-types; particularly those associated with bone formation. Formulations based on OPC have been used as dental restoratives and are now being investigated for their potential use in orthopaedic repair. Despite the current clinical interest in OPCs, very little is known about their chemistry in the physiological environment. In this respect, research to investigate aspects of the interactions between a white Portland cement (WPC) paste and simulated body fluid (SBF) has been carried out in vitro. Exposure to SBF has been found to promote the precipitation of a layer of 'bone-like' hydroxyapatite on the surface of WPC paste which underpins its ability to integrate with living tissue. The dissolution of portlandite and formation of calcite were also observed on contact with SBF.

Item Type: Article
Uncontrolled Keywords: cement paste, Portland cement, bioactivity
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:10
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2474

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