Inhibition of prandial and waterspray-induced rat grooming by 8-OH-DPAT
Hartley, J.E. and Montgomery, A.M.J. (2008) Inhibition of prandial and waterspray-induced rat grooming by 8-OH-DPAT. Journal of Psychopharmacology, 22 (7). pp. 746-752. ISSN 0269-8811 (doi:10.1177/0269881107082903)Full text not available from this repository.
The effects of 8-OH-DPAT treatment on rat grooming behaviour, elicited either prandially or in response to spraying with water were investigated. Dose (≤0.1 mg/kg s.c.) response studies employed momentary time sampling over 30 or 60 min with behaviour being scored in one of 6 or 7 (depending on food availability) mutually exclusive categories (feeding, active, scratching, face-grooming, body grooming, genital-grooming and resting) at 15 s intervals. In non-deprived rats, tested with wet mash available, feeding and activity frequencies were increased, but resting and total grooming were inhibited by 8-OH-DPAT. Face-, body- and genital-grooming occurred at higher levels than scratching, but all categories were reduced with reductions in scratching occurring at a lower dose (0.01 mg/kg). Misting rats with a fine water spray selectively increased body grooming and decreased activity without altering feeding, while 8-OH-DPAT increased feeding and reduced face-, body- and genital-grooming, without affecting already low levels of scratching. In misted rats, tested without food, 8-OH-DPAT reduced face-, body- and genital-grooming and increased resting. These results confirm i) that the water spray technique is a useful method for increasing grooming and ii) that 8-OH-DPAT has a suppressant effect on grooming independent of response competition from enhanced feeding.
|Uncontrolled Keywords:||8-OH-DPAT, grooming behaviour, microstructural analysis, obsessive-compulsive disorder, OCD|
|Subjects:||B Philosophy. Psychology. Religion > BF Psychology|
R Medicine > RM Therapeutics. Pharmacology
|School / Department / Research Groups:||School of Health & Social Care|
School of Health & Social Care > Department of Psychology & Counselling
|Last Modified:||03 Jan 2013 14:35|
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