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Microwave mediated reduction of heterocycle and fluorine containing nitroaromatics with Mo(CO)(6) and DBU

Microwave mediated reduction of heterocycle and fluorine containing nitroaromatics with Mo(CO)(6) and DBU

Spencer, John, Rathnam, Rajendra, Patel, Hiren and Anjum, Nazira (2008) Microwave mediated reduction of heterocycle and fluorine containing nitroaromatics with Mo(CO)(6) and DBU. Tetrahedron, 64 (44). pp. 10195-10200. ISSN 0040-4020 (doi:https://doi.org/10.1016/j.tet.2008.08.036)

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Abstract

Heterocycle containing nitroaromatics were reduced by Mo(CO)(6) and DBU in EtOH under microwave irradiation within 15 min. Under the same conditions, 4-fluoronitrobenzene was reduced to 4-fluoroaniline, whereas 2-chloro-1-fluoro-4-nitrobenzene afforded a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline. The extent of the competing SNAr/reduction process could be influenced by the nature of the solvent, with t-BuOH the inert solvent of choice. The latter was used as solvent for SNAr/reductions of 2-chloro-1-fluoro-4-nitrobenzene with S-nucleophiles to yield 3-chloro-4-mercaptoanilines. Crown Copyright (c) 2008 Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: amines, reduction, molybdenum, microwave, nitroaromatics
Subjects: Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science > School of Science (SCI)
Related URLs:
Last Modified: 10 Feb 2020 12:52
URI: http://gala.gre.ac.uk/id/eprint/2223

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