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Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids

Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids

Edwards, Alison A., Alexander, Bruce D., Fleet, George W.J. and Tranter, George E. (2008) Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids. Chirality, 20 (9). pp. 969-972. ISSN 0899-0042 (Print), 1520-636X (Online) (doi:10.1002/chir.20538)

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Abstract

Sugar amino acids and their oligomers, known as carbopeptoids, are commonly studied as foldamers. However, study of their conformational preference is often challenging when the adopted conformations are extended and/or disordered. This study is the first to explore the disordered nature of such carbopeptoids by utilizing a family of 2,5-trans carbopeptoids. An array of spectroscopic techniques has been used to investigate the conformational preference of these carbopeptoids. However, using this data alone it has not been possible to assign conformational preference as an ordered extended conformation or as a disordered family of closely related conformations. Computational methods need to be employed to achieve reliable interpretation of the spectroscopic data. Chirality, 2008. © 2008 Wiley-Liss, Inc.

Item Type: Article
Additional Information: [1] Special Issue: Proceedings of the 11th Conference on Circular Dichroism, Groningen, the Netherlands. [2] Paper presented at the 11th International Conference on Circular Dichroism, 2007, Groningen, Netherlands.
Uncontrolled Keywords: circular dichroism, sugar amino acids, conformation, extended, ordered, disordered, dipeptide isosteres, peptidomimetics
Subjects: Q Science > QP Physiology
Q Science > QC Physics
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Medway School of Pharmacy
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:10
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2191

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