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Practical solvent system selection for counter-current separation of pharmaceutical compounds

Practical solvent system selection for counter-current separation of pharmaceutical compounds

Dubant, Stéphane, Mathews, Ben, Higginson, Paul, Crook, Robert, Snowden, Martin and Mitchell, John ORCID: 0000-0003-2945-3292 (2008) Practical solvent system selection for counter-current separation of pharmaceutical compounds. Journal of Chromatography A, 1207 (1-2). pp. 190-192. ISSN 0021-9673 (doi:10.1016/j.chroma.2008.08.113)

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Abstract

Counter-current chromatography (CCC) is a technique that shows a lot of potential for large scale purification. Its usefulness in a "research and development" pharmaceutical environment has been investigated, and the conclusions are shown in this article. The use of CCC requires the development of an appropriate solvent system (a parameter of critical importance), a process which can be tedious. This article presents a novel strategy, combining a statistical approach and fast HPLC to generate a three-dimensional partition coefficient map and rapidly predict an optimal solvent system. This screen is performed in half a day and involves 9 experiments per solvent mixture. Test separations were performed using that screen to ensure the validity of the method.

Item Type: Article
Additional Information: [1] Available online: 5 September 2008. [2] Published in print: 17 October 2008. [3] Published in the Journal of Chromatography A, 2008, Volume 1207, Issues 1–2, pp. 190–192.
Uncontrolled Keywords: counter-current chromatography, solvent system selection, pharmaceutical, statistical approach
Subjects: R Medicine > RS Pharmacy and materia medica
T Technology > TP Chemical technology
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 09 Dec 2016 10:52
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2190

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