Controlled release from directly compressible theophylline buccal tablets

Boyapally, Harikrishna, Nukala, Ravi Kumar, Bhujval, Pranav and Douroumis, Dionysios (2010) Controlled release from directly compressible theophylline buccal tablets. Colloids and Surfaces B: Biointerfaces, 77 (2). pp. 227-233. ISSN 0927-7765

Abstract

The aim of the current study was the development of theophylline buccal adhesive tablets using direct compression. Buccal adhesive formulations were developed using a water soluble resin with various combinations of mucoadhesive polymers. The prepared theophylline tablets were evaluated for tensile strength, swelling capacity and ex vivo mucoadhesion performance. Ex vivo mucoadhesion was assessed using porcine gingival tissue and the peak detachment forces were found to be suitable for a buccal adhesive tablet with a maximum of 1.5N approximately. The effect of formulation composition on the release pattern was also investigated. Most formulations showed theophylline controlled release profiles depended on the grade and polymer ratio. The release mechanisms were found to fit Peppas' kinetic model over a period of 5h. In general the majority of the developed formulations presented suitable adhesion and controlled drug release. Copyright © 2010 Elsevier B.V. All rights reserved.

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