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Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles

Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles

Thomas, M.J.K., Slipper, I., Walunj, A., Jain, A., Favretto, M.E., Kallinteri, P. and Douroumis, Di. (2009) Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles. International Journal of Pharmaceutics, 387 (1-2). pp. 272-277. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2009.12.023)

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Abstract

Silica nanoparticles (MSNs) with a highly ordered mesoporous structures (103A) with cubic Im3 m have been synthesized using triblock copolymers with high poly(alkylene oxide) (EO) segments in acid media. The produced nanoparticles displayed large specific surface area (approximately 765 cm(2)/g) with an average particles size of 120 nm. The loading efficiency was assessed by incorporating three major antiepileptic active substances via passive loading and it was found to varying from 17 to 25%. The state of the adsorbed active agents was further analyzed using differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD). Dissolution studies revealed rapid release profiles within the first 3 h. The viability of 3T3 endothelial cells was not affected in the presence of MSNs indicating negligible cytotoxicity. 2009 Elsevier B.V. All rights reserved.

Item Type: Article
Additional Information: [1] First available online 16 December 2009. [2] Published in print as: 15 March 2010. [3] Published as: International Journal of Pharmaceutics, (2010), Volume 387, Issues 1–2, pp. 272–277.
Uncontrolled Keywords: mesoporous silica, sba-16, antiepileptic drugs, loading, cytotoxicity
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:10
URI: http://gala.gre.ac.uk/id/eprint/2169

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