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Microwave chemistry enabling the synthesis of biologically relevant amines

Microwave chemistry enabling the synthesis of biologically relevant amines

Spencer, John (2010) Microwave chemistry enabling the synthesis of biologically relevant amines. Future Medicinal Chemistry, 2 (2). pp. 161-168. ISSN 1756-8919 (Print), 1756-8927 (Online) (doi:10.4155/fmc.09.114)

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Abstract

Microwave-mediated chemistry, involving the reduction of nitroarenes with molybdenum hexacarbonyl as a stoichiometric reducing agent, has been employed in the synthesis of a range of anilines. Many of these reactions exhibit high levels of chemoselectivity, tolerating unsaturation, steric hindrance and halide substituents (I, Br, Cl or F), although the latter, under certain circumstances, can be displaced in concomitant SNAr/reduction processes. The reduction chemistry has been combined with palladium-catalyzed coupling and also used in the synthesis of important intermediates to kinase inhibitors or molecules with submicromolar antitrypanosomal activity. In selected cases, microwave-mediated routes have been compared with thermal (traditional oil bath) and flow reactor-mediated chemistries.

Item Type: Article
Uncontrolled Keywords: nitroarenes, anilines, microwave-mediated chemistry, molybdenum hexacarbonyl
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Related URLs:
Last Modified: 11 Aug 2015 16:12
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2104

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