The application of electrostatic dry powder deposition technology to coat drug-eluting stents
Nukala, Ravi Kumar, Boyapally, Harikrishna, Slipper, Ian J., Mendham, Andrew P. and Douroumis, Dennis (2009) The application of electrostatic dry powder deposition technology to coat drug-eluting stents. Pharmaceutical Research, 27 (1). pp. 72-81. ISSN 0724-8741 (Print), 1573-904X (Online) (doi:10.1007/s11095-009-0008-y)Full text not available from this repository.
Purpose: A novel methodology has been introduced to effectively coat intravascular stents with sirolimus-loaded polymeric microparticles.
Methods: Dry powders of the microparticulate formulation, consisting of non-erodible polymers, were produced by a supercritical, aerosol, solvent extraction system (ASES). A design of experiment (DOE) approach was conducted on the independent variables, such as organic/CO2 phase volume ratio, polymer weight and stirring-rate, while regression analysis was utilized to interpret the influence of all operational parameters on the dependent variable of particle size. The dry powders, so formed, entered an electric field created by corona charging and were sprayed on the earthed metal stent. Furthermore, the thermal stability of sirolimus was investigated to define the optimum conditions for fusion to the metal surfaces.
Results: The electrostatic dry powder deposition technology (EDPDT) was used on the metal strut followed by fusion to produce uniform, reproducible and accurate coatings. The coated stents exhibited sustained release profiles over 25 days, similar to commercial products. EDPDT-coated stents displayed significant reduced platelet adhesion.
Conclusions: EDPDT appeared to be a robust accurate and reproducible technology to coat eluting stents.
|Additional Information:|| An Official Journal of the American Association of Pharmaceutical Scientists.|
|Uncontrolled Keywords:||coating, drug eluting stents, electrostatic deposition, platelet adhesion, supercritical fluids|
|Subjects:||Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
|Faculty / Department / Research Groups:||Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||17 Oct 2016 09:09|
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