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The application of electrostatic dry powder deposition technology to coat drug-eluting stents

The application of electrostatic dry powder deposition technology to coat drug-eluting stents

Nukala, Ravi Kumar, Boyapally, Harikrishna, Slipper, Ian J., Mendham, Andrew P. and Douroumis, Dennis (2009) The application of electrostatic dry powder deposition technology to coat drug-eluting stents. Pharmaceutical Research, 27 (1). pp. 72-81. ISSN 0724-8741 (Print), 1573-904X (Online) (doi:10.1007/s11095-009-0008-y)

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Abstract

Purpose: A novel methodology has been introduced to effectively coat intravascular stents with sirolimus-loaded polymeric microparticles.
Methods: Dry powders of the microparticulate formulation, consisting of non-erodible polymers, were produced by a supercritical, aerosol, solvent extraction system (ASES). A design of experiment (DOE) approach was conducted on the independent variables, such as organic/CO2 phase volume ratio, polymer weight and stirring-rate, while regression analysis was utilized to interpret the influence of all operational parameters on the dependent variable of particle size. The dry powders, so formed, entered an electric field created by corona charging and were sprayed on the earthed metal stent. Furthermore, the thermal stability of sirolimus was investigated to define the optimum conditions for fusion to the metal surfaces.
Results: The electrostatic dry powder deposition technology (EDPDT) was used on the metal strut followed by fusion to produce uniform, reproducible and accurate coatings. The coated stents exhibited sustained release profiles over 25 days, similar to commercial products. EDPDT-coated stents displayed significant reduced platelet adhesion.
Conclusions: EDPDT appeared to be a robust accurate and reproducible technology to coat eluting stents.

Item Type: Article
Additional Information: [1] An Official Journal of the American Association of Pharmaceutical Scientists.
Uncontrolled Keywords: coating, drug eluting stents, electrostatic deposition, platelet adhesion, supercritical fluids
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:09
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/2087

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