Antioxidant and antiinflammatory effect of Epilobium parviflorum Schreb
Hevesi Tóth, Barbara, Houghton, P.J., Habtemariam, Solomon and Kéry, Á. (2009) Antioxidant and antiinflammatory effect of Epilobium parviflorum Schreb. Phytotherapy Research, 23 (5). pp. 719-724. ISSN 0951418X (doi:10.1002/ptr.2725)Full text not available from this repository.
Epilobium parviflorum Schreb. (Onagraceae) is used for the treatment of benign prostatic hyperplasia (BPH), but its biological action is not entirely identified. This paper aims to report data on E. parviflorum with respect to its antioxidant and antiinflammatory effects. The aqueous acetone extract of E. parviflorum showed higher antioxidant effect in the DPPH assay than well known antioxidants and inhibited the lipid peroxidation determined by the TBA assay (IC(50) = 2.37 +/- 0.12 mg/mL). In concentrations of 0.2-15.0 microg/mL the extract possessed a protective effect, comparable to catalase (250 IU/mL), against oxidative damage, generated in fibroblast cells. In the COX inhibition assay E. parviflorum decreased the PGE(2) release, so showing inhibition of the COX-enzyme (IC(50) = 1.4 +/- 0.1 microg/mL).
|Additional Information:|| Published online 23 December 2008.|
|Uncontrolled Keywords:||Epilobium parviflorum, BPH, DPPH, TBA, fibroblast, COX-enzyme|
|Subjects:||Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
|School / Department / Research Groups:||School of Science
Faculty of Engineering & Science > School of Science
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Faculty of Engineering & Science > School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||10 Oct 2012 09:32|
Actions (login required)