Antioxidant and antiinflammatory effect of Epilobium parviflorum Schreb
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Hevesi Tóth, Barbara, Houghton, P.J., Habtemariam, Solomon and Kéry, Á. (2009) Antioxidant and antiinflammatory effect of Epilobium parviflorum Schreb. Phytotherapy Research, 23 (5). pp. 719-724. ISSN 0951418X
Full text not available from this repository.Abstract
Epilobium parviflorum Schreb. (Onagraceae) is used for the treatment of benign prostatic hyperplasia (BPH), but its biological action is not entirely identified. This paper aims to report data on E. parviflorum with respect to its antioxidant and antiinflammatory effects. The aqueous acetone extract of E. parviflorum showed higher antioxidant effect in the DPPH assay than well known antioxidants and inhibited the lipid peroxidation determined by the TBA assay (IC(50) = 2.37 +/- 0.12 mg/mL). In concentrations of 0.2-15.0 microg/mL the extract possessed a protective effect, comparable to catalase (250 IU/mL), against oxidative damage, generated in fibroblast cells. In the COX inhibition assay E. parviflorum decreased the PGE(2) release, so showing inhibition of the COX-enzyme (IC(50) = 1.4 +/- 0.1 microg/mL).
| Item Type: | Article |
|---|---|
| Additional Information: | [1] Published online 23 December 2008. |
| Uncontrolled Keywords: | Epilobium parviflorum, BPH, DPPH, TBA, fibroblast, COX-enzyme |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| School / Department / Research Groups: | School of Science School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences |
| Related URLs: | |
| Last Modified: | 10 Oct 2012 10:32 |
| URI: | http://gala.gre.ac.uk/id/eprint/2059 |
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