Differential cytotoxic and prooxidnant activity of knipholone and knipholone anthrone
Habtemariam, S. and Dagne, E. (2009) Differential cytotoxic and prooxidnant activity of knipholone and knipholone anthrone. Planta Medica, 75 (9). SL5-SL5. ISSN 0032-0943 (doi:10.1055/s-0029-1234260)Full text not available from this repository.
Knipholone (KP) and knipholone anthrone (KA) are natural 4-phenylanthraquinone structural analogues with established differential biological effects including in vitro antioxidant  and antimicrobial properties . The present study was designed to investigate the comparative in vitro cytotoxic activity and the possible mechanism of action of these two compounds. We demonstrated that KA is by order of magnitude more cytotoxic to mammalian cells than KP. In parallel with the demonstrated cytotoxic effect, KA but not KP induces prooxidative DNA damage in the presence of copper ions. In order to establish the possible involvement of reactive oxygen species in the KA-mediated prooxidative effect, we investigated the protective effect of several metal chelators and reactive oxygen species scavengers. Our data suggest that reactive oxygen species such as hydrogen peroxide are involved and a good correlation between prooxidative action, antioxidant effect and cytotoxicity is established for these two structural analogues. The chemistry, pharmacology and potential medicinal/toxicological potential of these compounds are discussed.
|Additional Information:|| Published abstract for short lecture at: 57th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, 16-20 August 2009, Geneva, Switzerland.|
|Uncontrolled Keywords:||cytotoxic activity, knipholone anthrone, knipholone|
|Subjects:||Q Science > QD Chemistry|
R Medicine > RM Therapeutics. Pharmacology
|School / Department / Research Groups:||School of Science|
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||19 Feb 2013 16:14|
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