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Antibacterial and antifungal activity of cicerfuran and related 2-arylbenzofurans and stilbenes

Antibacterial and antifungal activity of cicerfuran and related 2-arylbenzofurans and stilbenes

Aslam, Shazia N., Stevenson, Philip C., Kokubun, Tetsuo and Hall, David R. (2009) Antibacterial and antifungal activity of cicerfuran and related 2-arylbenzofurans and stilbenes. Microbiological Research, 164 (2). pp. 191-195. ISSN 0944-5013 (doi:10.1016/j.micres.2006.11.012)

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Abstract

Cicerfuran, 2-(2-methoxy-4,5-methylenedioxyphenyl)-6-hydroxybenzofuran, is an antifungal phytoalexin previously isolated from the roots of chickpea, Cicer spp. The synthesis of cicerfuran, five 2-arylbenzofuran analogues and nine stilbene intermediates was reported recently. The antimicrobial activities of these compounds were evaluated against two species of bacteria, Bacillus subtilis and Pseudomonas syringae, and four species of filamentous fungi, Aspergillus niger, Botrytis cinerea, Cladosporium herbarum and Monilinia aucupariae. Stilbenes with a free hydroxyl group were active against both bacteria and fungi with MICs in the range 25–100 μg/ml. Cicerfuran was the only 2-arylbenzofuran that showed antimicrobial activity with MICs as low as 25 μg/ml. Some aspects of the structure–activity relationship are discussed.

Item Type: Article
Uncontrolled Keywords: cicerfuran, 2-arylbenzofurans, stilbenes, antifungal, antibacterial
Subjects: S Agriculture > SB Plant culture
Faculty / Department / Research Group: Faculty of Engineering & Science > Natural Resources Institute
Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department
Related URLs:
Last Modified: 05 Oct 2012 15:32
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/1914

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