Antibacterial and antifungal activity of cicerfuran and related 2-arylbenzofurans and stilbenes
Aslam, Shazia N., Stevenson, Philip C., Kokubun, Tetsuo and Hall, David R. (2009) Antibacterial and antifungal activity of cicerfuran and related 2-arylbenzofurans and stilbenes. Microbiological Research, 164 (2). pp. 191-195. ISSN 0944-5013 (doi:10.1016/j.micres.2006.11.012)Full text not available from this repository.
Cicerfuran, 2-(2-methoxy-4,5-methylenedioxyphenyl)-6-hydroxybenzofuran, is an antifungal phytoalexin previously isolated from the roots of chickpea, Cicer spp. The synthesis of cicerfuran, five 2-arylbenzofuran analogues and nine stilbene intermediates was reported recently. The antimicrobial activities of these compounds were evaluated against two species of bacteria, Bacillus subtilis and Pseudomonas syringae, and four species of filamentous fungi, Aspergillus niger, Botrytis cinerea, Cladosporium herbarum and Monilinia aucupariae. Stilbenes with a free hydroxyl group were active against both bacteria and fungi with MICs in the range 25–100 μg/ml. Cicerfuran was the only 2-arylbenzofuran that showed antimicrobial activity with MICs as low as 25 μg/ml. Some aspects of the structure–activity relationship are discussed.
|Uncontrolled Keywords:||cicerfuran, 2-arylbenzofurans, stilbenes, antifungal, antibacterial|
|Subjects:||S Agriculture > SB Plant culture|
|Faculty / Department / Research Groups:||Faculty of Engineering & Science > Natural Resources Institute
Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department
|Last Modified:||05 Oct 2012 15:32|
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