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Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants

Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants

Green, S., Roldo, M., Douroumis, Dionysios, Bouropoulos, Nikolaos, Lamprou, D. and Fatouros, Dimitrios G. (2009) Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants. Carbohydrate Research, 344 (7). pp. 901-907. ISSN 0008-6215 (doi:10.1016/j.carres.2009.02.022)

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Abstract

The aim of the current study was to evaluate the impact of chitosan derivatives, namely N-octyl-chitosan and N-octyl-O-sulfate chitosan, incorporated in calcium phosphate implants to the release profiles of model drugs. The rate and extent of calcein (on M.W. 650 Da) ED, and FITC-dextran (M.W. 40 kDa) on in vitro release were monitored by fluorescence spectroscopy. Results show that calcein release is affected by the type of chitosan derivative used. A higher percentage of model drug was released when the hydrophilic polymer N-octyl-sulfated chitosan was present in the tablets compared with the tablets containing the hydrophobic polymer N-octyl-chitosan. The release profiles of calcein or FD from tablets containing N-octyl-O-sulfate revealed a complete release for FD after 120 h compared with calcein where 20% of the drug was released over the same time period. These results suggest that the difference in the release profiles observed from the implants is dependent on the molecular weight of the model drugs. These data indicate the potential of chitosan derivatives in controlling the release profile of active compounds from calcium phosphate implants. (C) 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Additional Information: First published online: 28 February 2009
Uncontrolled Keywords: chitosan derivatives, hydroxyapatite, calcium phosphate implants, calcein, FITC-dextran, drug delivery
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 08 Dec 2016 15:18
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/1572

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