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Reductions in ambulatory blood pressure in young normotensive men and women after isometric exercise training and its relationship with cardiovascular reactivity

Reductions in ambulatory blood pressure in young normotensive men and women after isometric exercise training and its relationship with cardiovascular reactivity

Somani, Yasina B., Baross, Tony, Levy, Phillip, Zinszer, Kate, Milne, Kevin J., Swaine, Ian and McGowan, Cheri (2017) Reductions in ambulatory blood pressure in young normotensive men and women after isometric exercise training and its relationship with cardiovascular reactivity. Blood Pressure Monitoring, 22 (1). pp. 1-27. ISSN 1359-5237 (Print), 1473-5725 (Online) (doi:10.1097/MBP.0000000000000222)

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Abstract

There has been very little published work exploring the comparative effects of isometric exercise training (IRT) on blood pressure (BP) in men and women. Most of the previously published work has involved men used resting BP as the primary outcome variable. Early evidence suggests that IRT is particularly effective in older women and has a positive influence on ambulatory BP, a better predictor of disease risk. With the WHO now placing global emphasis on the primary prevention of hypertension, the goal of this proof-of-concept study were to (i) examine whether sex differences exist in the ambulatory BP-lowering effects of IRT in young, normotensive men and women and (ii) determine whether these reductions can be predicted by simple laboratory stress tasks (a 2-min sustained isometric contraction and a math task involving subtracting a two-digit number from a series of numbers). There were no differences in the IRT-induced reductions in 24-h (men: Δ4 mmHg, women: Δ4 mmHg), daytime (men: Δ3 mmHg, women: Δ4 mmHg), or night-time (men: Δ4 mmHg, women: Δ3 mmHg) ambulatory BP in men (n=13) and women (n=11) (P<0.05) and these changes were not associated with systolic BP reactivity to either stress task (all P>0.05). Our data suggest that lower ambulatory BP can be achieved, to a similar magnitude in young healthy women as well as men, with IRT; however, the BP-lowering effectiveness cannot be predicted by systolic BP reactivity. Taken together, this work heralds a potentially novel approach to the primary prevention of hypertension in both men and women and warrants further investigation in a larger clinical outcome trial.

Item Type: Article
Uncontrolled Keywords: Ambulatory blood pressure; Cardiovascular reactivity; AQ7 hypertension; Isometric exercise; Sex differences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Centre for Science and Medicine in Sport and Exercise
Faculty of Engineering & Science > Department of Life & Sports Sciences
Related URLs:
Last Modified: 01 Mar 2018 16:11
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/15646

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