Development and release mechanism of diltiazem HCl prolonged release matrix tablets
Boyapally, Harikrishna, Nukala, Ravi Kumar and Douroumis, Dionysios (2009) Development and release mechanism of diltiazem HCl prolonged release matrix tablets. Drug Delivery, 16 (2). pp. 67-74. ISSN 1071-7544 (doi:10.1080/10717540802586220)Full text not available from this repository.
A coated matrix tablet formulation has been used to develop controlled release diltiazem HCl (DIL) tablets. The developed drug delivery system provided prolonged drug release rates over a defined period of time. DIL tablets prepared using dry mixing and direct compression and the core consisted of hydrophilic and hydrophobic polymers such as hydroxypropylmethylcellulose (HPMC), Eudragits RLPO/RSPO, microcrystalline cellulose, and lactose. Tablets were coated with Eudragit NE 30D, and the influence of varying the inert hydrophobic polymers and the amount of the coating polymer were investigated. The release profile of the developed formulation was described by the Higuchi model. Stability trials up to 6 months displayed excellent reproducibility.
|Uncontrolled Keywords:||matrix tablets, direct compression, sustained release, higuchi model, diltiazem hydrochloride, drug stability, tablets|
|Subjects:||R Medicine > RM Therapeutics. Pharmacology|
|School / Department / Research Groups:||School of Science|
School of Science > Department of Pharmaceutical, Chemical & Environmental Sciences
|Last Modified:||09 Oct 2012 12:51|
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