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Development and biological evaluation of Iinkjet printed drug coatings on intravascular stent

Development and biological evaluation of Iinkjet printed drug coatings on intravascular stent

Scoutaris, Nikolaos, Chai, Feng, Blandine, Maurel, Sobocinski, Jonathan, Zhao, Min, Moffat, Jonathan G., Craig, Duncan Q., Martel, Bernard, Blanchemain, Nicolas and Douroumis, Dennis (2016) Development and biological evaluation of Iinkjet printed drug coatings on intravascular stent. Molecular Pharmaceutics, 13 (1). pp. 125-133. ISSN 1543-8384 (Print), 1543-8392 (Online) (doi:10.1021/acs.molpharmaceut.5b00570)

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Abstract

Inkjet–printing technology was used to apply biodegradable and biocompatible polymeric coatings of poly(D, L lactide) with the antiproliferative drugs simvastatin (SMV) and paclitaxel (PCX) on coronary metal stents. A piezoelectric dispenser applied coating patterns of very fine droplets (300 xL) and ink jetting was optimized to develop uniform, accurate and reproducible coatings of high yields on the stent strut. The drug loaded polymeric coatings were assed by scanning electron microscopy (SEM), atomic force microscopy (AFM) and transition thermal microscopy (TTM) where a phase separation was observed for SMV/PLA layers while PCX showed a uniform distribution within the polymer layers. Cytocompatibility studies of PLA coatings showed excellent cell adhesion with no decrease of cell viability and proliferation. In vivo stent implantation studies showed significant intra stent restenosis (ISR) for PXC/PLA and PLA plain coatings similar to marketed Presillion (bare metal) and Cypher (drug eluting) stents. The investigation of several cytokine levels after seven days of stent deployment showed no inflammatory response and hence no in vivo cytotoxicity related to PLA coatings. Inkjet printing can be employed as a robust coating technology for the development of drug eluting stents compared to the current conventional approaches.

Item Type: Article
Additional Information: Paper was originally submitted under the working title of "In vivo evaluation of biocompatible intravascular stents coated by inkjet printing"
Uncontrolled Keywords: drug eluting stents, inkjet printing, PLA, paclitaxel, simvastatin, cytokines, implantation
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 04 Dec 2017 11:18
Selected for GREAT 2016: GREAT a
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/15451

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