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Antioxidant and anti-α-glucosidase compounds from the rhizome of Peltiphyllum peltatum (Torr.) Engl.

Antioxidant and anti-α-glucosidase compounds from the rhizome of Peltiphyllum peltatum (Torr.) Engl.

Habtemariam, Solomon and Cowley, Raymond (2012) Antioxidant and anti-α-glucosidase compounds from the rhizome of Peltiphyllum peltatum (Torr.) Engl. Phytotherapy Research, 26 (11). pp. 1656-1660. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:10.1002/ptr.4626)

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Abstract

The antioxidant, anti-α-glucosidase and anticholinesterase effects of the alcohol extract of fresh underground rhizomes of Peltiphyllum peltatum were studied. A potent antioxidant activity accompanied by a selective α-glucosidase effect was observed for the crude extract. Further activity-guided fractionation (petroleum ether, chloroform, ethyl acetate, n-butanol and water) resulted in the identification of the ethyl acetate fraction with the highest antioxidant effect. Gallic acid, methyl-3-O-methyl gallate, catechin, gallocatechin, bergenin and 11-O-galloylbergenin were isolated from the ethyl acetate fraction. While all the isolated compounds did show a variable degree of radical scavenging effect, 11-O-galloylbergenin was identified as the selective α-glucosidase inhibitor. The isolation, structural elucidation and biological effects of these compounds are discussed.

Item Type: Article
Uncontrolled Keywords: Peltiphyllum peltatum, Saxifragaceae, Antioxidant, α-glucosidase, 11-O-galloylbergenin, Gallates, Catechins
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 17 Oct 2016 09:13
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/13455

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