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Antiinflammatory properties of the stem-bark of Anopyxis klaineana and its major constituent, Methyl Angolensate

Antiinflammatory properties of the stem-bark of Anopyxis klaineana and its major constituent, Methyl Angolensate

Mireku, Evelyn A., Mensah, Abraham Y., Mensah, Merlin L. K., Tocher, Derek A. and Habtemariam, Solomon (2014) Antiinflammatory properties of the stem-bark of Anopyxis klaineana and its major constituent, Methyl Angolensate. Phytotherapy Research, 28 (12). pp. 1855-1860. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:10.1002/ptr.5212)

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Abstract

Anopyxis klaineana (Pierre) Engl. (Rhizophoraceae) is one of the reputed West African folkloric medicines that has never been investigated for its pharmacological effects or phytochemical constituents. In the present study, the antiinflammatory properties of the stem-bark extracts were evaluated using the carrageenan-induced paw oedema model in chicks. The petroleum ether, ethyl acetate and methanol extracts all showed a time and dose-dependent antiinflammatory effect over the 5-h observation period. Phytochemical analysis of the most active extract (methanol extract) yielded the principal constituent that was identified as methyl angolensate through extensive spectroscopic and X-ray analysis studies. Although slightly less potent (ED50, 4.05 ± 0.0034 mg/kg, orally) than the positive control, diclofenac (ED50, 2.49 ± 0.023, intraperitoneally n = 5), this first ever compound isolated from A. klaineana showed promising antiinflammatory activity that may account to some of the reported medicinal uses of the plant.

Item Type: Article
Uncontrolled Keywords: Anopyxis klaineana, Rhizophoraceae, methyl angolensate, antiinflammatory, carrageenan
Subjects: R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science
Last Modified: 14 Oct 2016 09:30
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/12813

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