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Merder, Julian ORCID: https://orcid.org/0000-0002-5958-7016, Rigby, Robert A. ORCID: https://orcid.org/0000-0003-4787-623X, Mayr, Andreas ORCID: https://orcid.org/0000-0001-7106-9732, Heller, Gillian Z. ORCID: https://orcid.org/0000-0003-1270-1499, Kneib, Thomas ORCID: https://orcid.org/0000-0003-3390-0972, Umlauf, Nikolaus ORCID: https://orcid.org/0000-0003-2160-9803, De Bastiani, Fernanda ORCID: https://orcid.org/0000-0001-8532-639X, Stauffer, Reto ORCID: https://orcid.org/0000-0002-3798-5507, Tonkin, Jonathan D. ORCID: https://orcid.org/0000-0002-6053-291X, Logothetis, Nikos, Zeileis, Achim ORCID: https://orcid.org/0000-0003-0918-3766 and Stasinopoulos, Dimitrios M. (2026) Distributional regression using generalized additive models for location, scale and shape. Nature Reviews Methods Primers, 6:49. ISSN 2662-8449 (Online) (doi:10.1038/s43586-026-00498-z)