6-hydroxy-6-methyl-heptan-3-one

Scott, Flora H., Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A. and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2018) Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences, 5:28. ISSN 2296-889X (Online) (doi:10.3389/fmolb.2018.00028)

ageing

Scott, Flora H., Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A. and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2018) Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences, 5:28. ISSN 2296-889X (Online) (doi:10.3389/fmolb.2018.00028)

bioRxiv preprint server

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:10.1124/dmd.119.089995)

biosynthesis

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:10.1124/dmd.119.089995)

body weight

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:10.1016/j.bcp.2015.05.013)

C57BL/6J

Scott, Flora H., Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A. and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2018) Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences, 5:28. ISSN 2296-889X (Online) (doi:10.3389/fmolb.2018.00028)

cholesterol

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:10.1016/j.bcp.2015.05.013)

Drug Metabolism and Disposition

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:10.1124/dmd.119.089995)

FMO5

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:10.1016/j.bcp.2015.05.013)

FMO5 KO

Scott, Flora H., Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A. and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2018) Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences, 5:28. ISSN 2296-889X (Online) (doi:10.3389/fmolb.2018.00028)

genetic knock-out

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:10.1016/j.bcp.2015.05.013)

glucose

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:10.1016/j.bcp.2015.05.013)

humans

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:10.1124/dmd.119.089995)

hypotaurine

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:10.1124/dmd.119.089995)

malic enzyme 1

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:10.1016/j.bcp.2015.05.013)

medicine

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:10.1124/dmd.119.089995)

metabolic profiling

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:10.1016/j.bcp.2015.05.013)

Metabolite identification

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Dona, Anthony C., Kyriakides, Michael, Scott, Flora, Shephard, Elizabeth A., Varshavi, Dorsa and Veselkov, Kirill (2016) A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments. Computational and Structural Biotechnology Journal, 14. pp. 135-153. ISSN 2001-0370 (Print), 2001-0370 (Online) (doi:10.1016/j.csbj.2016.02.005)

metabolomics

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:10.1124/dmd.119.089995)

Scott, Flora H., Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A. and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2018) Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences, 5:28. ISSN 2296-889X (Online) (doi:10.3389/fmolb.2018.00028)

metabonomics

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:10.1124/dmd.119.089995)

Scott, Flora H., Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A. and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2018) Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences, 5:28. ISSN 2296-889X (Online) (doi:10.3389/fmolb.2018.00028)

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:10.1016/j.bcp.2015.05.013)

Metabonomics etabolomics

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Dona, Anthony C., Kyriakides, Michael, Scott, Flora, Shephard, Elizabeth A., Varshavi, Dorsa and Veselkov, Kirill (2016) A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments. Computational and Structural Biotechnology Journal, 14. pp. 135-153. ISSN 2001-0370 (Print), 2001-0370 (Online) (doi:10.1016/j.csbj.2016.02.005)

Molecular structure

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Dona, Anthony C., Kyriakides, Michael, Scott, Flora, Shephard, Elizabeth A., Varshavi, Dorsa and Veselkov, Kirill (2016) A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments. Computational and Structural Biotechnology Journal, 14. pp. 135-153. ISSN 2001-0370 (Print), 2001-0370 (Online) (doi:10.1016/j.csbj.2016.02.005)

Nuclear magnetic resonance (NMR) spectroscopy

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Dona, Anthony C., Kyriakides, Michael, Scott, Flora, Shephard, Elizabeth A., Varshavi, Dorsa and Veselkov, Kirill (2016) A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments. Computational and Structural Biotechnology Journal, 14. pp. 135-153. ISSN 2001-0370 (Print), 2001-0370 (Online) (doi:10.1016/j.csbj.2016.02.005)

plasma

Scott, Flora H., Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A. and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2018) Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences, 5:28. ISSN 2296-889X (Online) (doi:10.3389/fmolb.2018.00028)

taurine

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:10.1124/dmd.119.089995)

urine

Scott, Flora H., Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A. and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2018) Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences, 5:28. ISSN 2296-889X (Online) (doi:10.3389/fmolb.2018.00028)

white adipose tissue

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:10.1016/j.bcp.2015.05.013)