Items where Author is "Richardson, Simon C.W."

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activation agents Anthrax toxin anticancer conjugates antigen presenting cells antimalarial Antisense antitumor-activity APCs BCA bicinchoninic acid assay breast-cancer cancer CD Cell biology chemistry chloroquine circular dichroism complexes design dextrin drug delivery drugs Endocytosis endomembrane endosomolytic polymer Enteric estrogen-receptor modulators exocytosis ferrocifens fluorescence microscopy fluorescent microscopy gene delivery glutathione-S-transferase (GST) GST–GFP hVam6p immobilisation in-vitro inhibitors intracellular polymer localization intracellular trafficking IPTG lamina propria layer-by-layer assembly live-cell imaging LP lysosomes MALDI-TOF maternally derived antibodies matrix assisted laser desorption ionisation time o MDA Merkel cell polyomavirus nanomedicine nanomedicines nanoparticles Non-viral nuclear sequestration nucleus organelle organometallic chemistry palladium PEG-dilemma Peyer’s patch PLA2 poly(amidoamine) polymer conjugates polymer therapeutics polymers polyomavirus PP precatalysts PUMPT RNAi SANS SDS PAGE self-assembly silica siRNA small angle neutron scattering sodium dodecyl sulphate polyacrylamide gel electro subcellular fractionation synthetic protein T Antigen toxin trafficking tumor viruses tyrosine kinase-activity vaccine vaccine delivery systemsenteric VDS viral replication zeta-potential

Number of items: 101.

activation

Spencer, John, Mendham, Andrew P., Kotha, Arun K., Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649, Hillard, Elizabeth A., Jaouen, Gérard, Male, Louise and Hursthouse, Michael B. (2008) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transactions, 2009 (6). pp. 918-921. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:10.1039/B816249B)

agents

Spencer, John, Rathnam, Rajendra P., Montukuri, Mahesh, Kotha, Arun K., Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649, Hazrati, Ali, Hartley, John A., Male, Louise and Hursthouse, Michael B. (2009) Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity. Dalton Transactions (22). pp. 4299-4303. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:10.1039/b819061e)

Anthrax toxin

Dyer, Paul D.R., Shepherd, Thomas R., Gollings, Alexander S., Shorter, Susan A., Gorringe-Pattrick, Monique A. M., Tang, Chun-Kit, Cattoz, Beatrice N., Baillie, Les, Griffiths, Peter C. ORCID: https://orcid.org/0000-0002-6686-1271 and Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649 (2015) Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity. Journal of Controlled Release, 220 (A). pp. 316-328. ISSN 0168-3659 (doi:10.1016/j.jconrel.2015.10.054)

anticancer conjugates

Ferguson, Elaine L., Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649 and Duncan, Ruth (2010) Studies on the mechanism of action of dextrin−phospholipase A₂and its suitability for use in combination therapy. Molecular Pharmaceutics, 7 (2). pp. 510-521. ISSN 1543-8384 (Print), 1543-8392 (Online) (doi:10.1021/mp900232a)

antigen presenting cells

Pettit, Marie, Dyer, Paul D.R., Mitchell, John C. ORCID: https://orcid.org/0000-0003-2945-3292, Griffiths, Peter C. ORCID: https://orcid.org/0000-0002-6686-1271, Alexander, Bruce, Cattoz, Beatrice, Heenan, Richard K., King, Stephen M., Schweins, Ralf, Pullen, Frank, Wicks, Stephen R. and Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649 (2014) Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS). International Journal of Pharmaceutics, 468 (1-2). pp. 264-271. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2014.03.046)

antimalarial

Antisense

antitumor-activity

APCs

BCA

bicinchoninic acid assay

breast-cancer

cancer

CD

Cell biology

Pettit, Marie W., Griffiths, Peter ORCID: https://orcid.org/0000-0002-6686-1271, Ferruti, Paolo and Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649 (2011) Poly(amidoamine) polymers: soluble linear amphiphilic drug-delivery systems for genes, proteins and oligonucleotides. Therapeutic Delivery, 2 (7). pp. 907-917. ISSN 2041-5990 (doi:10.4155/tde.11.55)

chemistry

chloroquine

circular dichroism

complexes

design

dextrin

drug delivery

Dyer, Paul D.R., Kotha, Arun K., Pettit, Marie W. and Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649 (2013) Imaging select mammalian organelles using fluorescent microscopy: application to drug delivery. In: Weissig, Volkmar, Elbayoumi, Tamer and Olsen, Mark, (eds.) Methods in Molecular Biology: Cellular and subcellular nanotechnology. Methods in Molecular Biology, 991 . Humana Press, New York, USA, pp. 195-210. ISBN 9781627033350 (doi:10.1007/978-1-62703-336-7)

drugs

Endocytosis

Dyer, Paul D.R. and Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649 (2011) Delivery of biologics to select organelles – the role of biologically active polymers. Expert Opinion on Drug Delivery, 8 (4). pp. 403-407. ISSN 1742-5247 (doi:10.1517/17425247.2011.558080)

Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649, Wallom, Kerri-Lee, Ferguson, Elaine L., Deacon, Samuel P.E., Davies, Matthew W., Powell, Alison J., Piper, Robert C. and Duncan, Ruth (2008) The use of fluorescence microscopy to define polymer localisation to the late endocytic compartments in cells that are targets for drug delivery. Journal of Controlled Release, 127 (1). pp. 1-11. ISSN 0168-3659 (doi:10.1016/j.jconrel.2007.12.015)

endomembrane

endosomolytic polymer

Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649, Pattrick, Nicola G., Lavignac, Nathalie, Ferruti, Paolo and Duncan, Ruth (2009) Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo. Journal of Controlled Release, 142 (1). pp. 78-88. ISSN 0168-3659 (doi:10.1016/j.jconrel.2009.09.025)

Enteric

estrogen-receptor modulators

exocytosis

Liu, Xi, Hein, Jennifer, Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649, Basse, Per H., Toptan, Tuna, Moore, Patrick S., Gjoerup, Ole V. and Chang, Yuan (2011) Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus. The Journal of Biological Chemistry, 286 (19). pp. 17079-17090. ISSN 0021-9258 (Print), 1083-351X (Online) (doi:10.1074/jbc.M110.192856)

ferrocifens

fluorescence microscopy

Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649 (2010) Tracking intracellular polymer localization via fluorescence microscopy. In: Weissig, Volkmar and D'Souza, Gerard G.M., (eds.) Organelle-Specific Pharmaceutical Nanotechnology. John Wiley & Sons, Inc., pp. 177-192. ISBN 9780470631652

fluorescent microscopy

gene delivery

Griffiths, Peter C. ORCID: https://orcid.org/0000-0002-6686-1271, Mauro, Nicolo, Murphy, Damien M., Carter, Emma, Richardson, Simon C.W. ORCID: https://orcid.org/0000-0002-7927-0649, Dyer, Paul and Ferruti, Paolo (2013) Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems. Macromolecular Bioscience, 13 (5). pp. 641-649. ISSN 1616-5187 (Print), 1616-5195 (Online) (doi:10.1002/mabi.201200462)