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Items where Author is "Leach, Michael J."

Items where Author is "Leach, Michael J."

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binding site BW202W92 BW203W92 central nervous system diseases central nervous system drugs crystal structures and drug design cytokines gated sodium channels lamotrigine lamotrigines Multiple sclerosis neurodegenerative diseases phospholipids polyunsaturated fatty acids pyrimidines sodium channel blockers structured phospholipids treatment of multiple sclerosis triazines triglycerides use patent voltage gated Na+ channel inhibitors voltage-gated Na+ channel blockers voltage-gated Na+ channel inhibitors voltage-gated sodium channels X-ray crystallographic structures
Number of items: 57.

binding site

Riddall, Dieter R., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Garthwaite, John (2006) A novel drug binding site on voltage-gated sodium channels in rat brain. Molecular Pharmacology, 69 (1). pp. 278-287. ISSN 1521-0111 (Online) (doi:10.1124/mol.105.015966)

BW202W92

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325, Jenkins, Terence C. and Chowdhry, Babur Z. (2010) An absolute structure template for a unique voltage-gated sodium channel binding site. MedChemComm, 1 (1). pp. 45-49. ISSN 2040-2503 (Print), 2040-2511 (Online) (doi:10.1039/C0MD00043D)

Riddall, Dieter R., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Garthwaite, John (2006) A novel drug binding site on voltage-gated sodium channels in rat brain. Molecular Pharmacology, 69 (1). pp. 278-287. ISSN 1521-0111 (Online) (doi:10.1124/mol.105.015966)

BW203W92

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325, Jenkins, Terence C. and Chowdhry, Babur Z. (2010) An absolute structure template for a unique voltage-gated sodium channel binding site. MedChemComm, 1 (1). pp. 45-49. ISSN 2040-2503 (Print), 2040-2511 (Online) (doi:10.1039/C0MD00043D)

central nervous system diseases

University of Greenwich (2010) Cyclic triazo sodium channel blockers. 12801937.

central nervous system drugs

Palmer, Rex A., Potter, Brian S., Helliwell, Madeleine, Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Central nervous system drugs: Low temperature X-ray structures of (I) the base 5-(2,3-dichlorophenyl)-2,4-diamino-6-fluoromethyl-pyrimidine (4030W92) and (II) 5-(2,6-dichlorophenyl)-1-H-2,4-diamino-6-methyl-pyrimidine methanesulphonic acid salt (227C89). Journal of Chemical Crystallography, 39 (1). pp. 36-41. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9428-5)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) X-ray crystallographic structures of two lamotrigine analogues: (I) 3,5-diamino-6-(2-chlorophenyl)-1,2,4-triazine water solvate and (II) 3,5-diamino-6-(3,6-dichlorophenyl)-1,2,4-triazine methanol solvate. Journal of Chemical Crystallography, 38 (5). pp. 387-392. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9320-3)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray crystallographic structures of two lamotrigine analogues: (I) 2-methyl,3-amino, 5-imino-6-(2,3-dichlorophenyl)-1,2,4-triazine water solvate and (II) 2-methyl,3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate, hemi-hydrate. Journal of Chemical Crystallography, 38 (4). pp. 255-260. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9318-x)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray structures of two crystalline forms (I) and (II) of the pyrimidine derivative and sodium channel blocker BW1003C87: 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine. Journal of Chemical Crystallography, 38 (6). pp. 407-411. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9319-9)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2007) X-ray crystallographic structures of neuroprotective pyrimidine derivatives: (I) the mesylate salt of BW1003C87 and (II) sipatrigine base. Journal of Chemical Crystallography, 37 (11). pp. 771-777. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-007-9248-z)

crystal structures and drug design

Palmer, Rex A., Potter, Brian S., Helliwell, Madeleine, Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Central nervous system drugs: Low temperature X-ray structures of (I) the base 5-(2,3-dichlorophenyl)-2,4-diamino-6-fluoromethyl-pyrimidine (4030W92) and (II) 5-(2,6-dichlorophenyl)-1-H-2,4-diamino-6-methyl-pyrimidine methanesulphonic acid salt (227C89). Journal of Chemical Crystallography, 39 (1). pp. 36-41. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9428-5)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) X-ray crystallographic structures of two lamotrigine analogues: (I) 3,5-diamino-6-(2-chlorophenyl)-1,2,4-triazine water solvate and (II) 3,5-diamino-6-(3,6-dichlorophenyl)-1,2,4-triazine methanol solvate. Journal of Chemical Crystallography, 38 (5). pp. 387-392. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9320-3)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray crystallographic structures of two lamotrigine analogues: (I) 2-methyl,3-amino, 5-imino-6-(2,3-dichlorophenyl)-1,2,4-triazine water solvate and (II) 2-methyl,3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate, hemi-hydrate. Journal of Chemical Crystallography, 38 (4). pp. 255-260. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9318-x)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray structures of two crystalline forms (I) and (II) of the pyrimidine derivative and sodium channel blocker BW1003C87: 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine. Journal of Chemical Crystallography, 38 (6). pp. 407-411. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9319-9)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2007) X-ray crystallographic structures of neuroprotective pyrimidine derivatives: (I) the mesylate salt of BW1003C87 and (II) sipatrigine base. Journal of Chemical Crystallography, 37 (11). pp. 771-777. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-007-9248-z)

cytokines

BTG International Ltd (2009) Structured phospholipids. US2009/0036410 A1.

BTG International Limited (2006) Treatment of cytokine dysregulation by using sn-2 gamma-linolenoyl, gamma-dihomolinolenoyl or arachidonoyl patty acid glycerol monoesters. WO2006/092622A1.

gated sodium channels

Palmer, Rex A., Potter, Brian S., Helliwell, Madeleine, Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Central nervous system drugs: Low temperature X-ray structures of (I) the base 5-(2,3-dichlorophenyl)-2,4-diamino-6-fluoromethyl-pyrimidine (4030W92) and (II) 5-(2,6-dichlorophenyl)-1-H-2,4-diamino-6-methyl-pyrimidine methanesulphonic acid salt (227C89). Journal of Chemical Crystallography, 39 (1). pp. 36-41. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9428-5)

lamotrigine

Palmer, Rex A., Potter, Brian S., Helliwell, Madeleine, Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Central nervous system drugs: Low temperature X-ray structures of (I) the base 5-(2,3-dichlorophenyl)-2,4-diamino-6-fluoromethyl-pyrimidine (4030W92) and (II) 5-(2,6-dichlorophenyl)-1-H-2,4-diamino-6-methyl-pyrimidine methanesulphonic acid salt (227C89). Journal of Chemical Crystallography, 39 (1). pp. 36-41. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9428-5)

BTG International Limited (2004) Treatment of neurodegenerative conditions. US 2004/0229873 Al.

lamotrigines

Palmer, Rex A., Potter, Brian S., Helliwell, Madeleine, Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Central nervous system drugs: Low temperature X-ray structures of (I) the base 5-(2,3-dichlorophenyl)-2,4-diamino-6-fluoromethyl-pyrimidine (4030W92) and (II) 5-(2,6-dichlorophenyl)-1-H-2,4-diamino-6-methyl-pyrimidine methanesulphonic acid salt (227C89). Journal of Chemical Crystallography, 39 (1). pp. 36-41. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9428-5)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) X-ray crystallographic structures of two lamotrigine analogues: (I) 3,5-diamino-6-(2-chlorophenyl)-1,2,4-triazine water solvate and (II) 3,5-diamino-6-(3,6-dichlorophenyl)-1,2,4-triazine methanol solvate. Journal of Chemical Crystallography, 38 (5). pp. 387-392. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9320-3)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray crystallographic structures of two lamotrigine analogues: (I) 2-methyl,3-amino, 5-imino-6-(2,3-dichlorophenyl)-1,2,4-triazine water solvate and (II) 2-methyl,3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate, hemi-hydrate. Journal of Chemical Crystallography, 38 (4). pp. 255-260. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9318-x)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray structures of two crystalline forms (I) and (II) of the pyrimidine derivative and sodium channel blocker BW1003C87: 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine. Journal of Chemical Crystallography, 38 (6). pp. 407-411. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9319-9)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2007) X-ray crystallographic structures of neuroprotective pyrimidine derivatives: (I) the mesylate salt of BW1003C87 and (II) sipatrigine base. Journal of Chemical Crystallography, 37 (11). pp. 771-777. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-007-9248-z)

Multiple sclerosis

BTG International Limited (2010) Cytokine modulators using cyclic glycerides of essential polyunsaturated fatty acids. PT1853254 (E).

BTG International Ltd (2009) Structured phospholipids. US2009/0036410 A1.

BTG International Limited (2008) Treatment of neurodegenerative conditions. GB2442161/B.

BTG International Limited (2004) Treatment of neurodegenerative conditions. US 2004/0229873 Al.

neurodegenerative diseases

BTG International Limited (2008) Treatment of neurodegenerative conditions. GB2442161/B.

BTG International Limited (2006) Treatment of cytokine dysregulation by using sn-2 gamma-linolenoyl, gamma-dihomolinolenoyl or arachidonoyl patty acid glycerol monoesters. PCT/GB2006/000778.

phospholipids

BTG International Limited (2006) Structured phospholipids. WO2006/056783 A2.

polyunsaturated fatty acids

BTG International Limited (2010) Cytokine modulators using cyclic glycerides of essential polyunsaturated fatty acids. PT1853254 (E).

BTG International Limited (2006) Treatment of cytokine dysregulation by using sn-2 gamma-linolenoyl, gamma-dihomolinolenoyl or arachidonoyl patty acid glycerol monoesters. PCT/GB2006/000778.

BTG International Limited (2004) Use of triglyceride oils containing gamma-linolenic residues and linoleic acid residues for the treatment of neurodegenerative disease. WO2004/100943 A1.

pyrimidines

Palmer, Rex A., Potter, Brian S., Helliwell, Madeleine, Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Central nervous system drugs: Low temperature X-ray structures of (I) the base 5-(2,3-dichlorophenyl)-2,4-diamino-6-fluoromethyl-pyrimidine (4030W92) and (II) 5-(2,6-dichlorophenyl)-1-H-2,4-diamino-6-methyl-pyrimidine methanesulphonic acid salt (227C89). Journal of Chemical Crystallography, 39 (1). pp. 36-41. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9428-5)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray structures of two crystalline forms (I) and (II) of the pyrimidine derivative and sodium channel blocker BW1003C87: 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine. Journal of Chemical Crystallography, 38 (6). pp. 407-411. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9319-9)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2007) X-ray crystallographic structures of neuroprotective pyrimidine derivatives: (I) the mesylate salt of BW1003C87 and (II) sipatrigine base. Journal of Chemical Crystallography, 37 (11). pp. 771-777. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-007-9248-z)

sodium channel blockers

University of Greenwich (2010) Cyclic triazo sodium channel blockers. 12801937.

structured phospholipids

BTG International Ltd (2009) Structured phospholipids. US2009/0036410 A1.

treatment of multiple sclerosis

BTG International Limited (2006) Treatment of cytokine dysregulation by using sn-2 gamma-linolenoyl, gamma-dihomolinolenoyl or arachidonoyl patty acid glycerol monoesters. WO2006/092622A1.

BTG International Limited (2006) Structured phospholipids. WO2006/056783 A2.

BTG International Limited (2005) Treatment of neurodegenerative conditions. WO2005/018632/A1.

BTG International Limited (2004) Use of triglyceride oils containing gamma-linolenic residues and linoleic acid residues for the treatment of neurodegenerative disease. WO2004/100943 A1.

triazines

University of Greenwich (2010) Cyclic triazo sodium channel blockers. 12801937.

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) X-ray crystallographic structures of two lamotrigine analogues: (I) 3,5-diamino-6-(2-chlorophenyl)-1,2,4-triazine water solvate and (II) 3,5-diamino-6-(3,6-dichlorophenyl)-1,2,4-triazine methanol solvate. Journal of Chemical Crystallography, 38 (5). pp. 387-392. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9320-3)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray crystallographic structures of two lamotrigine analogues: (I) 2-methyl,3-amino, 5-imino-6-(2,3-dichlorophenyl)-1,2,4-triazine water solvate and (II) 2-methyl,3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate, hemi-hydrate. Journal of Chemical Crystallography, 38 (4). pp. 255-260. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9318-x)

triglycerides

BTG International Limited (2008) Treatment of neurodegenerative conditions. GB2442161/B.

use patent

BTG International Limited (2004) Treatment of neurodegenerative conditions. US 2004/0229873 Al.

voltage gated Na+ channel inhibitors

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) X-ray crystallographic structures of two lamotrigine analogues: (I) 3,5-diamino-6-(2-chlorophenyl)-1,2,4-triazine water solvate and (II) 3,5-diamino-6-(3,6-dichlorophenyl)-1,2,4-triazine methanol solvate. Journal of Chemical Crystallography, 38 (5). pp. 387-392. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9320-3)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray crystallographic structures of two lamotrigine analogues: (I) 2-methyl,3-amino, 5-imino-6-(2,3-dichlorophenyl)-1,2,4-triazine water solvate and (II) 2-methyl,3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate, hemi-hydrate. Journal of Chemical Crystallography, 38 (4). pp. 255-260. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9318-x)

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Low temperature X-ray structures of two crystalline forms (I) and (II) of the pyrimidine derivative and sodium channel blocker BW1003C87: 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine. Journal of Chemical Crystallography, 38 (6). pp. 407-411. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9319-9)

voltage-gated Na+ channel blockers

Palmer, Rex A., Potter, Brian S., Helliwell, Madeleine, Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2008) Central nervous system drugs: Low temperature X-ray structures of (I) the base 5-(2,3-dichlorophenyl)-2,4-diamino-6-fluoromethyl-pyrimidine (4030W92) and (II) 5-(2,6-dichlorophenyl)-1-H-2,4-diamino-6-methyl-pyrimidine methanesulphonic acid salt (227C89). Journal of Chemical Crystallography, 39 (1). pp. 36-41. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-008-9428-5)

voltage-gated Na+ channel inhibitors

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Chowdhry, Babur Z. (2007) X-ray crystallographic structures of neuroprotective pyrimidine derivatives: (I) the mesylate salt of BW1003C87 and (II) sipatrigine base. Journal of Chemical Crystallography, 37 (11). pp. 771-777. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-007-9248-z)

voltage-gated sodium channels

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325, Jenkins, Terence C. and Chowdhry, Babur Z. (2010) An absolute structure template for a unique voltage-gated sodium channel binding site. MedChemComm, 1 (1). pp. 45-49. ISSN 2040-2503 (Print), 2040-2511 (Online) (doi:10.1039/C0MD00043D)

Riddall, Dieter R., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325 and Garthwaite, John (2006) A novel drug binding site on voltage-gated sodium channels in rat brain. Molecular Pharmacology, 69 (1). pp. 278-287. ISSN 1521-0111 (Online) (doi:10.1124/mol.105.015966)

X-ray crystallographic structures

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID logoORCID: https://orcid.org/0000-0002-9859-1325, Jenkins, Terence C. and Chowdhry, Babur Z. (2010) An absolute structure template for a unique voltage-gated sodium channel binding site. MedChemComm, 1 (1). pp. 45-49. ISSN 2040-2503 (Print), 2040-2511 (Online) (doi:10.1039/C0MD00043D)

This list was generated on Tue Dec 31 17:43:47 2024 UTC.