1. Metabolic phenotyping 2. Metabonomics 3. Metabolomics 4. Drug Discovery 5. Drug Development 6. Attrition 7. Target Discovery 8. Drug Efficacy 9. Drug Safety 10. Pharmacometabonomics

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2018) Applications of metabolic phenotyping in pharmaceutical research and development. In: Lindon, John C., Nicholson, Jeremy K. and Holmes, Elaine, (eds.) The Handbook of Metabolic Phenotyping. Elsevier, pp. 407-448. ISBN 978-0128122938

biofluids

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Lindon, John and Nicholson, Jeremy (2016) Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. In: Nicholson, Jeremy, Darzi, A, Lindon, John and Holmes, Elaine, (eds.) Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, pp. 137-165. ISBN 9780128003442 (doi:10.1016/B978-0-12-800344-2.00006-9)

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)

chemometrics

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)

classification

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)

disease

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)

metabolic entropy

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. and Nicholson, Jeremy K. (2019) A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Trends in Pharmacological Sciences, 40 (10). pp. 763-773. ISSN 0165-6147 (Print), 1873-3735 (Online) (doi:10.1016/j.tips.2019.08.004)

metabolites

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)

metabolomics

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. and Nicholson, Jeremy K. (2019) A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Trends in Pharmacological Sciences, 40 (10). pp. 763-773. ISSN 0165-6147 (Print), 1873-3735 (Online) (doi:10.1016/j.tips.2019.08.004)

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Lindon, John and Nicholson, Jeremy (2016) Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. In: Nicholson, Jeremy, Darzi, A, Lindon, John and Holmes, Elaine, (eds.) Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, pp. 137-165. ISBN 9780128003442 (doi:10.1016/B978-0-12-800344-2.00006-9)

metabonomics

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. and Nicholson, Jeremy K. (2019) A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Trends in Pharmacological Sciences, 40 (10). pp. 763-773. ISSN 0165-6147 (Print), 1873-3735 (Online) (doi:10.1016/j.tips.2019.08.004)

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Lindon, John and Nicholson, Jeremy (2016) Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. In: Nicholson, Jeremy, Darzi, A, Lindon, John and Holmes, Elaine, (eds.) Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, pp. 137-165. ISBN 9780128003442 (doi:10.1016/B978-0-12-800344-2.00006-9)

Cunningham, Katharine, Claus, Sandrine P., Lindon, John C., Holmes, Elaine, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Nicholson, Jeremy K. and Coen, Muireann (2012) Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response. Journal of Proteome Research, 11 (9). pp. 4630-4642. ISSN 1535-3893 (Print), 1535-3907 (Online) (doi:10.1021/pr300430u)

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2006) Metabolic applications in clinical pharmaceutical R&D. In: Lindon, John C., Nicholson, Jeremy K. and Holmes, Elaine, (eds.) The Handbook of Metabonomics and Metabolomics. Elsevier, Amsterdam, The Netherlands, pp. 279-287. ISBN 9780444528414

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)

metabotypes

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. and Nicholson, Jeremy K. (2019) A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Trends in Pharmacological Sciences, 40 (10). pp. 763-773. ISSN 0165-6147 (Print), 1873-3735 (Online) (doi:10.1016/j.tips.2019.08.004)

NMR spectroscopy

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Lindon, John and Nicholson, Jeremy (2016) Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. In: Nicholson, Jeremy, Darzi, A, Lindon, John and Holmes, Elaine, (eds.) Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, pp. 137-165. ISBN 9780128003442 (doi:10.1016/B978-0-12-800344-2.00006-9)

Cunningham, Katharine, Claus, Sandrine P., Lindon, John C., Holmes, Elaine, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Nicholson, Jeremy K. and Coen, Muireann (2012) Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response. Journal of Proteome Research, 11 (9). pp. 4630-4642. ISSN 1535-3893 (Print), 1535-3907 (Online) (doi:10.1021/pr300430u)

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)

pattern recognition

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)

personalised medicine

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. and Nicholson, Jeremy K. (2019) A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Trends in Pharmacological Sciences, 40 (10). pp. 763-773. ISSN 0165-6147 (Print), 1873-3735 (Online) (doi:10.1016/j.tips.2019.08.004)

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Lindon, John and Nicholson, Jeremy (2016) Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. In: Nicholson, Jeremy, Darzi, A, Lindon, John and Holmes, Elaine, (eds.) Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, pp. 137-165. ISBN 9780128003442 (doi:10.1016/B978-0-12-800344-2.00006-9)

pharmacometabolomics

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Lindon, John and Nicholson, Jeremy (2016) Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. In: Nicholson, Jeremy, Darzi, A, Lindon, John and Holmes, Elaine, (eds.) Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, pp. 137-165. ISBN 9780128003442 (doi:10.1016/B978-0-12-800344-2.00006-9)

pharmacometabonomics

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. and Nicholson, Jeremy K. (2019) A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Trends in Pharmacological Sciences, 40 (10). pp. 763-773. ISSN 0165-6147 (Print), 1873-3735 (Online) (doi:10.1016/j.tips.2019.08.004)

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Lindon, John and Nicholson, Jeremy (2016) Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. In: Nicholson, Jeremy, Darzi, A, Lindon, John and Holmes, Elaine, (eds.) Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, pp. 137-165. ISBN 9780128003442 (doi:10.1016/B978-0-12-800344-2.00006-9)

Cunningham, Katharine, Claus, Sandrine P., Lindon, John C., Holmes, Elaine, Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Nicholson, Jeremy K. and Coen, Muireann (2012) Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response. Journal of Proteome Research, 11 (9). pp. 4630-4642. ISSN 1535-3893 (Print), 1535-3907 (Online) (doi:10.1021/pr300430u)

precision medicine

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. and Nicholson, Jeremy K. (2019) A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Trends in Pharmacological Sciences, 40 (10). pp. 763-773. ISSN 0165-6147 (Print), 1873-3735 (Online) (doi:10.1016/j.tips.2019.08.004)

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Lindon, John and Nicholson, Jeremy (2016) Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. In: Nicholson, Jeremy, Darzi, A, Lindon, John and Holmes, Elaine, (eds.) Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, pp. 137-165. ISBN 9780128003442 (doi:10.1016/B978-0-12-800344-2.00006-9)

systems medicine

Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482, Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. and Nicholson, Jeremy K. (2019) A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Trends in Pharmacological Sciences, 40 (10). pp. 763-773. ISSN 0165-6147 (Print), 1873-3735 (Online) (doi:10.1016/j.tips.2019.08.004)

toxicity

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy ORCID: https://orcid.org/0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)