Items where Author is "Coles, Simon J."

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1′-dicarbaldehyde 2 3-dihydro-2H-indol-2-ones 3-Methylidene-Oxindoles 3-triazole-containing hydroxamic acids 4-substituted methylidene oxindoles absolute configuration aldehydes amides anticancer benzodiazepines biaryls bioinorganic biphenylamides bond boronic acid catalysis Civet click chemistry copper copper ligand design C−H activation catalysis radical DFT EPR propargylamines cross coupling cyclic di-amino acid peptide cyclic dipeptide cyclic dipeptides cyclisation dbu Dihydropyran DKP ring conformations Electrochemistry evaluation ferrocene ferrocene-1 ferrocene-based 1 flow chemistry fluorinated pyran growth-factor receptor HDAC inhibition and activity HDAC inhibitor heterocycles heterocyclic chemistry hydrogen bonds hydroxamic acid indium trichloride Indolin-2-one (oxindole) kinase inhibitor kinase inhibitors Knoevenagel condensation Lewis acid metallocene methylidene-1 microwave microwave irradiation microwave-assisted synthesis microwaves MukaiyamaeAldolesilyl-Prins reaction nucleophilic substitution organic chemistry organic synthesis oxazoles parallel synthesis pi interactions pipecolic acid piperazines piperidines Prins reaction Pyran reduction silyl-Prins reaction solid state x-ray crystallography supported reagents Suzuki coupling synthesis trypanosoma x-ray crystal structure X-ray crystallography Z'

Number of items: 94.

1′-dicarbaldehyde

Spencer, John, Nielsen, Birthe ORCID: 0000-0002-0849-4987 , Thomas, Michael J.K., Male, Louise and Coles, Simon J. (2011) The Knoevenagel product of indolin-2-one and ferrocene-1,1′-dicarbaldehyde. Acta Crystallographica Section C, 67 (7). m245-m248. ISSN 0108-2701 (doi:https://doi.org/10.1107/S0108270111021536)

2

Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:https://doi.org/10.1039/c1md00203a)

3-dihydro-2H-indol-2-ones

Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:https://doi.org/10.1039/C1MT00017A)

3-Methylidene-Oxindoles

Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333 (Print), 1520-6041 (Online) (doi:https://doi.org/10.1021/om200278j)

3-triazole-containing hydroxamic acids

4-substituted methylidene oxindoles

Tizzard, Graham J., Coles, Simon J., Edwards, Mark, Onyeabo, Romanus Oforbike, Allen, Mark and Spencer, John (2013) Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles. Chemistry Central Journal, 7 (1):182. ISSN 1752-153X (doi:https://doi.org/10.1186/1752-153X-7-182)

absolute configuration

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0098-3)

aldehydes

Dobbs, Adrian P. ORCID: 0000-0002-7241-7118 , Guesné, Sebastien J.J., Hursthouse, Michael B. and Coles, Simon J. (2003) [Letter] The aza-silyl-prins reaction: A novel method for the synthesis of trans-2,6-tetrahydropyridines. Synlett (11). pp. 1740-1742. ISSN 0936-5214 (Print), 1437-2096 (Online) (doi:https://doi.org/10.1055/s-2003-41434)

amides

Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia ORCID: 0000-0003-1402-8496 , Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:https://doi.org/10.1016/j.tetlet.2012.05.025)

anticancer

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters, 2 (5). pp. 358-362. ISSN 1948-5875 (doi:10.1021.ml100295v)

benzodiazepines

Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896 (doi:https://doi.org/10.1016/j.bmc.2011.01.010)

biaryls

Spencer, John, Baltus, Christine B., Patel, Hiren, Press, Neil J., Callear, Samantha K., Male, Louise and Coles, Simon J. (2010) Microwave-mediated synthesis of an arylboronate library. ACS Combinatorial Science, 2011 (13):1. pp. 24-31. ISSN 2156-8952 (Print), 2156-8944 (Online) (doi:https://doi.org/10.1021/co100011g)

bioinorganic

biphenylamides

Baltus, Christine, Press, Neil J., Antonijevic, Milan D. ORCID: 0000-0002-5847-7886 , Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020 (doi:https://doi.org/10.1016/j.tet.2012.08.062)

bond

Spencer, John, Chowdhry, Babur Z., Hamid, Samiyah, Mendham, Andrew P., Male, Louise, Coles, Simon J. and Hursthouse, Michael B. (2010) Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. Acta Crystallographica Section C: Crystal Structure Communications, 66 (2). o71-o78. ISSN 0108-2701 (Print), 1600-5759 (Online) (doi:https://doi.org/10.1107/S0108270109054134)

boronic acid

catalysis

Sampani, Stavroula I., Zdorichenko, Victor, Danopoulou, Marianna, Leech, Matthew C., Lam, Kevin ORCID: 0000-0003-1481-9212 , Abdul-Sada, Alaa, Cox, Brian, Tizzard, Graham J., Coles, Simon J., Tsipis, Athanassios and Kostakis, George E. (2019) Shedding light on the use of Cu(ii)-salen complexes in the A3 coupling reaction. Dalton Transactions, 2020:49. pp. 289-299. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:https://doi.org/10.1039/C9DT04146J)

Civet

Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green, Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M. and Dobbs, Adrian P. ORCID: 0000-0002-7241-7118 (2011) On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet. Tetrahedron, 67 (27-28). pp. 5107-5124. ISSN 0040-4020 (doi:https://doi.org/10.1016/j.tet.2011.05.019)

click chemistry

copper

copper ligand design C−H activation catalysis radical DFT EPR propargylamines

Devonport, Jack, Sully, Lauren, Boudalis, Athanassios K., Hassell-Hart, Storm, Leech, Matthew C., Lam, Kevin ORCID: 0000-0003-1481-9212 , Abdul-Sada, Alaa, Tizzard, Graham J., Coles, Simon J., Spencer Evans, John, Vargas, Alfredo and Kostaki, George E. (2021) Room temperature Cu(II) radical-triggered Alkyne C−H activation. Journal of the American Chemical Society AU. ISSN 2691-3704 (Print), 2691-3704 (Online) (doi:https://doi.org/10.1021/jacsau.1c00310)

cross coupling

cyclic di-amino acid peptide

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0097-4)

cyclic dipeptide

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0097-4)

cyclic dipeptides

cyclisation

dbu

Dihydropyran

DKP ring conformations

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0097-4)

Electrochemistry

evaluation

ferrocene

ferrocene-1

ferrocene-based 1

flow chemistry

Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039 (doi:https://doi.org/10.1016/j.tetlet.2012.01.081)

Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:https://doi.org/10.1016/j.tetlet.2011.07.147)

fluorinated pyran

growth-factor receptor

HDAC inhibition and activity

HDAC inhibitor

heterocycles

heterocyclic chemistry

Mittapalli, Ramana Reddy, Coles, Simon J., Klooster, Wim T. and Dobbs, Adrian P. ORCID: 0000-0002-7241-7118 (2021) A stereoselective aza-prins reaction: rapid access to enantiopure piperidines and pipecolic acids. Journal of Organic Chemistry, 86 (3). pp. 2076-2089. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:https://doi.org/10.1021/acs.joc.0c01897)

hydrogen bonds

hydroxamic acid

indium trichloride

Dobbs, Adrian P. ORCID: 0000-0002-7241-7118 , Guesné, Sebastien J. J., Martinović, Saša, Coles, Simon J. and Hursthouse, Michael B. (2003) A versatile indium trichloride mediated Prins-type reaction to unsaturated heterocycles. The Journal of Organic Chemistry, 68 (20). pp. 7880-7883. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:https://doi.org/10.1021/jo034981k)

Indolin-2-one (oxindole)

kinase inhibitor

kinase inhibitors

Knoevenagel condensation

Lewis acid

metallocene

methylidene-1

microwave

microwave irradiation

microwave-assisted synthesis

microwaves

MukaiyamaeAldolesilyl-Prins reaction

nucleophilic substitution

organic chemistry

organic synthesis

oxazoles

parallel synthesis

pi interactions

pipecolic acid

piperazines

piperidines

Prins reaction

Pyran

reduction

silyl-Prins reaction

solid state x-ray crystallography

supported reagents

Suzuki coupling

synthesis

trypanosoma

x-ray crystal structure

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:https://doi.org/10.1007/s10870-011-0097-4)

X-ray crystallography

Z'

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