1′-dicarbaldehyde

Spencer, John, Nielsen, Birthe ORCID: https://orcid.org/0000-0002-0849-4987, Thomas, Michael J.K., Male, Louise and Coles, Simon J. (2011) The Knoevenagel product of indolin-2-one and ferrocene-1,1′-dicarbaldehyde. Acta Crystallographica Section C, 67 (7). m245-m248. ISSN 0108-2701 (doi:10.1107/S0108270111021536)

2

Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)

3-dihydro-2H-indol-2-ones

Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)

3-Methylidene-Oxindoles

Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333 (Print), 1520-6041 (Online) (doi:10.1021/om200278j)

3-triazole-containing hydroxamic acids

Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)

4-substituted methylidene oxindoles

Tizzard, Graham J., Coles, Simon J., Edwards, Mark, Onyeabo, Romanus Oforbike, Allen, Mark and Spencer, John (2013) Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles. Chemistry Central Journal, 7 (1):182. ISSN 1752-153X (doi:10.1186/1752-153X-7-182)

absolute configuration

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)

aldehydes

Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118, Guesné, Sebastien J.J., Hursthouse, Michael B. and Coles, Simon J. (2003) [Letter] The aza-silyl-prins reaction: A novel method for the synthesis of trans-2,6-tetrahydropyridines. Synlett (11). pp. 1740-1742. ISSN 0936-5214 (Print), 1437-2096 (Online) (doi:10.1055/s-2003-41434)

amides

Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)

anticancer

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters, 2 (5). pp. 358-362. ISSN 1948-5875 (doi:10.1021.ml100295v)

benzodiazepines

Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896 (doi:10.1016/j.bmc.2011.01.010)

biaryls

Spencer, John, Baltus, Christine B., Patel, Hiren, Press, Neil J., Callear, Samantha K., Male, Louise and Coles, Simon J. (2010) Microwave-mediated synthesis of an arylboronate library. ACS Combinatorial Science, 2011 (13):1. pp. 24-31. ISSN 2156-8952 (Print), 2156-8944 (Online) (doi:10.1021/co100011g)

bioinorganic

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters, 2 (5). pp. 358-362. ISSN 1948-5875 (doi:10.1021.ml100295v)

biphenylamides

Baltus, Christine, Press, Neil J., Antonijevic, Milan D. ORCID: https://orcid.org/0000-0002-5847-7886, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020 (doi:10.1016/j.tet.2012.08.062)

bond

Spencer, John, Chowdhry, Babur Z., Hamid, Samiyah, Mendham, Andrew P., Male, Louise, Coles, Simon J. and Hursthouse, Michael B. (2010) Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. Acta Crystallographica Section C: Crystal Structure Communications, 66 (2). o71-o78. ISSN 0108-2701 (Print), 1600-5759 (Online) (doi:10.1107/S0108270109054134)

boronic acid

Spencer, John, Baltus, Christine B., Patel, Hiren, Press, Neil J., Callear, Samantha K., Male, Louise and Coles, Simon J. (2010) Microwave-mediated synthesis of an arylboronate library. ACS Combinatorial Science, 2011 (13):1. pp. 24-31. ISSN 2156-8952 (Print), 2156-8944 (Online) (doi:10.1021/co100011g)

catalysis

Sampani, Stavroula I., Zdorichenko, Victor, Danopoulou, Marianna, Leech, Matthew C., Lam, Kevin ORCID: https://orcid.org/0000-0003-1481-9212, Abdul-Sada, Alaa, Cox, Brian, Tizzard, Graham J., Coles, Simon J., Tsipis, Athanassios and Kostakis, George E. (2019) Shedding light on the use of Cu(ii)-salen complexes in the A3 coupling reaction. Dalton Transactions, 2020:49. pp. 289-299. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:10.1039/C9DT04146J)

Civet

Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green, Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2011) On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet. Tetrahedron, 67 (27-28). pp. 5107-5124. ISSN 0040-4020 (doi:10.1016/j.tet.2011.05.019)

click chemistry

Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)

copper

Sampani, Stavroula I., Zdorichenko, Victor, Danopoulou, Marianna, Leech, Matthew C., Lam, Kevin ORCID: https://orcid.org/0000-0003-1481-9212, Abdul-Sada, Alaa, Cox, Brian, Tizzard, Graham J., Coles, Simon J., Tsipis, Athanassios and Kostakis, George E. (2019) Shedding light on the use of Cu(ii)-salen complexes in the A3 coupling reaction. Dalton Transactions, 2020:49. pp. 289-299. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:10.1039/C9DT04146J)

copper ligand design C−H activation catalysis radical DFT EPR propargylamines

Devonport, Jack, Sully, Lauren, Boudalis, Athanassios K., Hassell-Hart, Storm, Leech, Matthew C., Lam, Kevin ORCID: https://orcid.org/0000-0003-1481-9212, Abdul-Sada, Alaa, Tizzard, Graham J., Coles, Simon J., Spencer Evans, John, Vargas, Alfredo and Kostaki, George E. (2021) Room temperature Cu(II) radical-triggered Alkyne C−H activation. Journal of the American Chemical Society AU. ISSN 2691-3704 (Print), 2691-3704 (Online) (doi:10.1021/jacsau.1c00310)

cross coupling

Baltus, Christine, Press, Neil J., Antonijevic, Milan D. ORCID: https://orcid.org/0000-0002-5847-7886, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020 (doi:10.1016/j.tet.2012.08.062)

cyclic di-amino acid peptide

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0097-4)

cyclic dipeptide

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0097-4)

cyclic dipeptides

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)

cyclisation

Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)

dbu

Spencer, John, Chowdhry, Babur Z., Hamid, Samiyah, Mendham, Andrew P., Male, Louise, Coles, Simon J. and Hursthouse, Michael B. (2010) Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. Acta Crystallographica Section C: Crystal Structure Communications, 66 (2). o71-o78. ISSN 0108-2701 (Print), 1600-5759 (Online) (doi:10.1107/S0108270109054134)

Dihydropyran

Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green, Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2011) On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet. Tetrahedron, 67 (27-28). pp. 5107-5124. ISSN 0040-4020 (doi:10.1016/j.tet.2011.05.019)

DKP ring conformations

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0097-4)

Electrochemistry

Sampani, Stavroula I., Zdorichenko, Victor, Danopoulou, Marianna, Leech, Matthew C., Lam, Kevin ORCID: https://orcid.org/0000-0003-1481-9212, Abdul-Sada, Alaa, Cox, Brian, Tizzard, Graham J., Coles, Simon J., Tsipis, Athanassios and Kostakis, George E. (2019) Shedding light on the use of Cu(ii)-salen complexes in the A3 coupling reaction. Dalton Transactions, 2020:49. pp. 289-299. ISSN 1477-9226 (Print), 1477-9234 (Online) (doi:10.1039/C9DT04146J)

evaluation

Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)

ferrocene

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters, 2 (5). pp. 358-362. ISSN 1948-5875 (doi:10.1021.ml100295v)

ferrocene-1

Spencer, John, Nielsen, Birthe ORCID: https://orcid.org/0000-0002-0849-4987, Thomas, Michael J.K., Male, Louise and Coles, Simon J. (2011) The Knoevenagel product of indolin-2-one and ferrocene-1,1′-dicarbaldehyde. Acta Crystallographica Section C, 67 (7). m245-m248. ISSN 0108-2701 (doi:10.1107/S0108270111021536)

ferrocene-based 1

Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)

flow chemistry

Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.01.081)

Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.07.147)

fluorinated pyran

Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green, Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2011) On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet. Tetrahedron, 67 (27-28). pp. 5107-5124. ISSN 0040-4020 (doi:10.1016/j.tet.2011.05.019)

growth-factor receptor

Spencer, John, Chowdhry, Babur Z., Hamid, Samiyah, Mendham, Andrew P., Male, Louise, Coles, Simon J. and Hursthouse, Michael B. (2010) Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. Acta Crystallographica Section C: Crystal Structure Communications, 66 (2). o71-o78. ISSN 0108-2701 (Print), 1600-5759 (Online) (doi:10.1107/S0108270109054134)

HDAC inhibition and activity

Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Alwi, Sharifah S. Syed, Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner, James E, (2012) Click JAHAs: Conformationally restricted ferrocene-based histone deacetylase inhibitors. Medicinal Chemistry Communication, 3 (1). pp. 61-64. ISSN 2040-2503 (online) (doi:10.1039/c1md00203a)

HDAC inhibitor

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters, 2 (5). pp. 358-362. ISSN 1948-5875 (doi:10.1021.ml100295v)

heterocycles

Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)

Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.07.147)

heterocyclic chemistry

Mittapalli, Ramana Reddy, Coles, Simon J., Klooster, Wim T. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2021) A stereoselective aza-prins reaction: rapid access to enantiopure piperidines and pipecolic acids. Journal of Organic Chemistry, 86 (3). pp. 2076-2089. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:10.1021/acs.joc.0c01897)

hydrogen bonds

Baltus, Christine, Press, Neil J., Antonijevic, Milan D. ORCID: https://orcid.org/0000-0002-5847-7886, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020 (doi:10.1016/j.tet.2012.08.062)

hydroxamic acid

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Syed Alwi, Sharifah S., Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E. and Heightman, Tom D. (2011) Synthesis and biological evaluation of JAHAs: ferrocene-based histone deacetylase inhibitors. ACS Medicinal Chemistry Letters, 2 (5). pp. 358-362. ISSN 1948-5875 (doi:10.1021.ml100295v)

indium trichloride

Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118, Guesné, Sebastien J. J., Martinović, Saša, Coles, Simon J. and Hursthouse, Michael B. (2003) A versatile indium trichloride mediated Prins-type reaction to unsaturated heterocycles. The Journal of Organic Chemistry, 68 (20). pp. 7880-7883. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:10.1021/jo034981k)

Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118, Guesné, Sebastien J.J., Hursthouse, Michael B. and Coles, Simon J. (2003) [Letter] The aza-silyl-prins reaction: A novel method for the synthesis of trans-2,6-tetrahydropyridines. Synlett (11). pp. 1740-1742. ISSN 0936-5214 (Print), 1437-2096 (Online) (doi:10.1055/s-2003-41434)

Indolin-2-one (oxindole)

Spencer, John, Nielsen, Birthe ORCID: https://orcid.org/0000-0002-0849-4987, Thomas, Michael J.K., Male, Louise and Coles, Simon J. (2011) The Knoevenagel product of indolin-2-one and ferrocene-1,1′-dicarbaldehyde. Acta Crystallographica Section C, 67 (7). m245-m248. ISSN 0108-2701 (doi:10.1107/S0108270111021536)

kinase inhibitor

Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333 (Print), 1520-6041 (Online) (doi:10.1021/om200278j)

kinase inhibitors

Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)

Knoevenagel condensation

Tizzard, Graham J., Coles, Simon J., Edwards, Mark, Onyeabo, Romanus Oforbike, Allen, Mark and Spencer, John (2013) Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles. Chemistry Central Journal, 7 (1):182. ISSN 1752-153X (doi:10.1186/1752-153X-7-182)

Spencer, John, Nielsen, Birthe ORCID: https://orcid.org/0000-0002-0849-4987, Thomas, Michael J.K., Male, Louise and Coles, Simon J. (2011) The Knoevenagel product of indolin-2-one and ferrocene-1,1′-dicarbaldehyde. Acta Crystallographica Section C, 67 (7). m245-m248. ISSN 0108-2701 (doi:10.1107/S0108270111021536)

Lewis acid

Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green, Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2011) On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet. Tetrahedron, 67 (27-28). pp. 5107-5124. ISSN 0040-4020 (doi:10.1016/j.tet.2011.05.019)

metallocene

Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)

Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333 (Print), 1520-6041 (Online) (doi:10.1021/om200278j)

methylidene-1

Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)

microwave

Spencer, John, Baltus, Christine B., Patel, Hiren, Press, Neil J., Callear, Samantha K., Male, Louise and Coles, Simon J. (2010) Microwave-mediated synthesis of an arylboronate library. ACS Combinatorial Science, 2011 (13):1. pp. 24-31. ISSN 2156-8952 (Print), 2156-8944 (Online) (doi:10.1021/co100011g)

microwave irradiation

Spencer, John, Chowdhry, Babur Z., Hamid, Samiyah, Mendham, Andrew P., Male, Louise, Coles, Simon J. and Hursthouse, Michael B. (2010) Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. Acta Crystallographica Section C: Crystal Structure Communications, 66 (2). o71-o78. ISSN 0108-2701 (Print), 1600-5759 (Online) (doi:10.1107/S0108270109054134)

microwave-assisted synthesis

Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.01.081)

microwaves

Baltus, Christine, Press, Neil J., Antonijevic, Milan D. ORCID: https://orcid.org/0000-0002-5847-7886, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020 (doi:10.1016/j.tet.2012.08.062)

Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)

Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896 (doi:10.1016/j.bmc.2011.01.010)

Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.07.147)

MukaiyamaeAldolesilyl-Prins reaction

Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green, Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2011) On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet. Tetrahedron, 67 (27-28). pp. 5107-5124. ISSN 0040-4020 (doi:10.1016/j.tet.2011.05.019)

nucleophilic substitution

Spencer, John, Baltus, Christine B., Patel, Hiren, Press, Neil J., Callear, Samantha K., Male, Louise and Coles, Simon J. (2010) Microwave-mediated synthesis of an arylboronate library. ACS Combinatorial Science, 2011 (13):1. pp. 24-31. ISSN 2156-8952 (Print), 2156-8944 (Online) (doi:10.1021/co100011g)

organic chemistry

Mittapalli, Ramana Reddy, Coles, Simon J., Klooster, Wim T. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2021) A stereoselective aza-prins reaction: rapid access to enantiopure piperidines and pipecolic acids. Journal of Organic Chemistry, 86 (3). pp. 2076-2089. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:10.1021/acs.joc.0c01897)

organic synthesis

Mittapalli, Ramana Reddy, Coles, Simon J., Klooster, Wim T. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2021) A stereoselective aza-prins reaction: rapid access to enantiopure piperidines and pipecolic acids. Journal of Organic Chemistry, 86 (3). pp. 2076-2089. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:10.1021/acs.joc.0c01897)

oxazoles

Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.01.081)

parallel synthesis

Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.05.025)

Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2012) Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Letters, 53 (13). pp. 1656-1659. ISSN 0040-4039 (doi:10.1016/j.tetlet.2012.01.081)

Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896 (doi:10.1016/j.bmc.2011.01.010)

Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.07.147)

pi interactions

Spencer, John, Chowdhry, Babur Z., Hamid, Samiyah, Mendham, Andrew P., Male, Louise, Coles, Simon J. and Hursthouse, Michael B. (2010) Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. Acta Crystallographica Section C: Crystal Structure Communications, 66 (2). o71-o78. ISSN 0108-2701 (Print), 1600-5759 (Online) (doi:10.1107/S0108270109054134)

pipecolic acid

Mittapalli, Ramana Reddy, Coles, Simon J., Klooster, Wim T. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2021) A stereoselective aza-prins reaction: rapid access to enantiopure piperidines and pipecolic acids. Journal of Organic Chemistry, 86 (3). pp. 2076-2089. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:10.1021/acs.joc.0c01897)

piperazines

Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J. (2011) Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries. Tetrahedron Letters, 52 (45). pp. 5905-5909. ISSN 0040-4039 (online) (doi:10.1016/j.tetlet.2011.07.147)

piperidines

Mittapalli, Ramana Reddy, Coles, Simon J., Klooster, Wim T. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2021) A stereoselective aza-prins reaction: rapid access to enantiopure piperidines and pipecolic acids. Journal of Organic Chemistry, 86 (3). pp. 2076-2089. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:10.1021/acs.joc.0c01897)

Prins reaction

Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green, Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2011) On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet. Tetrahedron, 67 (27-28). pp. 5107-5124. ISSN 0040-4020 (doi:10.1016/j.tet.2011.05.019)

Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118, Guesné, Sebastien J. J., Martinović, Saša, Coles, Simon J. and Hursthouse, Michael B. (2003) A versatile indium trichloride mediated Prins-type reaction to unsaturated heterocycles. The Journal of Organic Chemistry, 68 (20). pp. 7880-7883. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:10.1021/jo034981k)

Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118, Guesné, Sebastien J.J., Hursthouse, Michael B. and Coles, Simon J. (2003) [Letter] The aza-silyl-prins reaction: A novel method for the synthesis of trans-2,6-tetrahydropyridines. Synlett (11). pp. 1740-1742. ISSN 0936-5214 (Print), 1437-2096 (Online) (doi:10.1055/s-2003-41434)

Pyran

Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green, Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2011) On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet. Tetrahedron, 67 (27-28). pp. 5107-5124. ISSN 0040-4020 (doi:10.1016/j.tet.2011.05.019)

reduction

Spencer, John, Chowdhry, Babur Z., Hamid, Samiyah, Mendham, Andrew P., Male, Louise, Coles, Simon J. and Hursthouse, Michael B. (2010) Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. Acta Crystallographica Section C: Crystal Structure Communications, 66 (2). o71-o78. ISSN 0108-2701 (Print), 1600-5759 (Online) (doi:10.1107/S0108270109054134)

silyl-Prins reaction

Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green, Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M. and Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118 (2011) On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet. Tetrahedron, 67 (27-28). pp. 5107-5124. ISSN 0040-4020 (doi:10.1016/j.tet.2011.05.019)

Dobbs, Adrian P. ORCID: https://orcid.org/0000-0002-7241-7118, Guesné, Sebastien J. J., Martinović, Saša, Coles, Simon J. and Hursthouse, Michael B. (2003) A versatile indium trichloride mediated Prins-type reaction to unsaturated heterocycles. The Journal of Organic Chemistry, 68 (20). pp. 7880-7883. ISSN 0022-3263 (Print), 1520-6904 (Online) (doi:10.1021/jo034981k)

solid state x-ray crystallography

Tizzard, Graham J., Coles, Simon J., Edwards, Mark, Onyeabo, Romanus Oforbike, Allen, Mark and Spencer, John (2013) Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles. Chemistry Central Journal, 7 (1):182. ISSN 1752-153X (doi:10.1186/1752-153X-7-182)

supported reagents

Spencer, John, Baltus, Christine B., Patel, Hiren, Press, Neil J., Callear, Samantha K., Male, Louise and Coles, Simon J. (2010) Microwave-mediated synthesis of an arylboronate library. ACS Combinatorial Science, 2011 (13):1. pp. 24-31. ISSN 2156-8952 (Print), 2156-8944 (Online) (doi:10.1021/co100011g)

Suzuki coupling

Spencer, John, Baltus, Christine B., Patel, Hiren, Press, Neil J., Callear, Samantha K., Male, Louise and Coles, Simon J. (2010) Microwave-mediated synthesis of an arylboronate library. ACS Combinatorial Science, 2011 (13):1. pp. 24-31. ISSN 2156-8952 (Print), 2156-8944 (Online) (doi:10.1021/co100011g)

synthesis

Spencer, John, Amin, Jahangir, Callear, Samantha K., Tizzard, Graham J., Coles, Simon J., Coxhead, Peter and Guille, Matthew (2011) Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics, 3 (6). pp. 600-608. ISSN 1756-5901 (doi:10.1039/C1MT00017A)

trypanosoma

Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & Medicinal Chemistry, 19 (5). pp. 1802-1815. ISSN 0968-0896 (doi:10.1016/j.bmc.2011.01.010)

x-ray crystal structure

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: Cyclo(L-HomoCySH-L-HomoCySH). Journal of Chemical Crystallography, 41 (9). pp. 1328-1334. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0098-3)

Mendham, Andrew P., Spencer, John, Chowdhry, Babur Z., Dines, Trevor J., Mujahid, Muhammad, Palmer, Rex A., Tizzard, Graham J. and Coles, Simon J. (2011) X-ray crystallographic structure of the cyclic di-amino acid peptide: N,N′-Diacetyl-cyclo(Gly-Gly). Journal of Chemical Crystallography, 41 (9). pp. 1323-1327. ISSN 1074-1542 (Print), 1572-8854 (Online) (doi:10.1007/s10870-011-0097-4)

X-ray crystallography

Baltus, Christine, Press, Neil J., Antonijevic, Milan D. ORCID: https://orcid.org/0000-0002-5847-7886, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020 (doi:10.1016/j.tet.2012.08.062)

Z'

Baltus, Christine, Press, Neil J., Antonijevic, Milan D. ORCID: https://orcid.org/0000-0002-5847-7886, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020 (doi:10.1016/j.tet.2012.08.062)