Indomethacin, In-line monitoring, Reflectance; Transmission, Near infrared spectroscopy, Process analytical technology, Hot-melt extrusion, Molecular solutions, Raman mapping

Islam, Muhammad T., Scoutaris, Nikolaos, Maniruzzaman, Mohammed, Moradiya, Hiren G., Halsey, Sheelagh, Bradley, Michael, Chowdhry, Babur, Snowden, Martin ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing. European Journal of Pharmaceutics and Biopharmaceutics, 96. pp. 106-116. ISSN 0939-6411 (Print), 1873-3441 (Online) (doi:https://doi.org/10.1016/j.ejpb.2015.06.021)

Pharmaceutical cocrystals; hot melt extrusion (HME); cocrystallisation;

Moradiya, Hiren G. (2014) Development of cocrystals of water insoluble active substances with inactive excipients by using hot melt extrusion. PhD thesis, University of Greenwich.

continuous cocrystallisation, carbamazepine, trans-cinnamic acid, melt extrusion processing

Moradiya, Hiren G., Islam, Muhammad T., Halsey, Sheelagh, Maniruzzaman, Mohammed, Chowdhry, Babur Z., Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2014) Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing. CrystEngComm, 16 (17). pp. 3573-3583. ISSN 1466-8033 (doi:https://doi.org/10.1039/c3ce42457j)

polymorph spectroscopy

Moradiya, Hiren, Islam, Muhammad T., Woollam, Grahame R., Slipper, Ian J., Halsey, Sheelagh, Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2013) Continuous cocrystallization for dissolution rate optimization of a poorly water-soluble drug. Crystal Growth & Design, 14 (1). pp. 189-198. ISSN 1528-7483 (Print), 1528-7505 (Online) (doi:https://doi.org/10.1021/cg401375a)

polymorphs, transformation, variable-temperature XRPD, caprolactam, extrudates, near-infrared spectroscopy, Polynorphism, drug delivery, crystals

Maniruzzaman, Mohammed, Islam, Muhammad T., Moradiya, Hiren G., Halsey, Sheelagh A., Slipper, Ian J., Chowdhry, Babur Z., Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2014) Prediction of polymorphic transformations of paracetamol in solid dispersions. Journal of Pharmaceutical Sciences, 103 (6). pp. 1819-1828. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:https://doi.org/10.1002/jps.23992)