Acryl-EZE, Astree e-tongue, Eudragit L100, taste masking, TS5000Z

Maniruzzaman, Mohammed and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) An in-vitro-in-vivo taste assessment of bitter drug: comparative electronic tongues study. Journal of Pharmacy and Pharmacology, 67 (1). pp. 43-55. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/jphp.12319)

Maniruzzaman, Mohammed and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) An in-vitro–in-vivo taste assessment of bitter drug: comparative electronic tongues study. Journal of Pharmacy and Pharmacology, 67 (1). pp. 43-55. ISSN 0022-573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/jphp.12319)

Amorphous; Continuous manufacturing; Energy dispersive X-ray; Oral strips; Surface analysis

Maniruzzaman, Mohammed, Farias, Smirna, Slipper, Ian J., Boateng, Joshua S. ORCID: 0000-0002-6310-729X , Chowdhry, Babur Z., Nair, Arun and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2016) Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing. Journal of Pharmacy and Pharmacology, 68 (7). pp. 890-900. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/jphp.12569)

Bitter APIs; Hot melt extrusion; Inter-molecular interactions; Modified release; Molecular dispersion; Taste assessment; Taste masking

Maniruzzaman, Mohammed, Boateng, Joshua ORCID: 0000-0002-6310-729X , Chowdhry, Babur, Snowden, Martin ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2013) A review on the taste masking of bitter APIs: Hot-melt extrusion (HME) evaluation. Drug Development and Industrial Pharmacy, 40 (2). pp. 145-156. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:https://doi.org/10.3109/03639045.2013.804833)

Extrusion; Solid dispersions; Excipients; Drug – excipient interactions dissolution.

Maniruzzaman, M., Ross, S.A., Islam, M.T, Scoutaris, N., Nair, A. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2017) Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients. Drug Development and Industrial Pharmacy, 43 (6). pp. 947-957. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:https://doi.org/10.1080/03639045.2017.1287716)

Granulations; DoE; QbD; Dissolutions; Twin screw; Raman; DVS

Maniruzzaman, Mohammed, Nair, Arun, Renault, Maxcene, Nandi, Uttom ORCID: 0000-0003-1777-3862 , Scoutaris, Nicholaos, Farnish, Richard, Bradley, Mike, Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Continuous twin-screw granulation for enhancing the dissolution of poorly water soluble drug. International Journal of Pharmaceutics Special Issue on "Continuous Manufacturing and Process Analytical Tools”, 496 (1). ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:https://doi.org/10.1016/j.ijpharm.2015.09.025)

HME, taste masking

Maniruzzaman, M., Boateng, J. ORCID: 0000-0002-6310-729X and Douroumis, D. ORCID: 0000-0002-3782-0091 (2011) Taste masking of bitter APIs by using hot melt extrusion (HME). In: AAPS Journal. American Association of Pharmaceutical Sciences, Arlington, VA, USA, T3273-T3273. ISSN 1550-7416 (on-line)

Hot melt extrusion; Taste masking; Solubility increase; Process technology; Formulation

Maniruzzaman, Mohammed, Boateng, Joshua S. ORCID: 0000-0002-6310-729X , Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2012) A review of hot-melt extrusion: process technology to pharmaceutical products [Review article]. ISRN Pharmaceutics, 2012:436763. pp. 1-9. ISSN 2090-6145 (Print), 2090-6153 (Online) (doi:https://doi.org/10.5402/2012/436763)

Indomethacin, In-line monitoring, Reflectance; Transmission, Near infrared spectroscopy, Process analytical technology, Hot-melt extrusion, Molecular solutions, Raman mapping

Islam, Muhammad T., Scoutaris, Nikolaos, Maniruzzaman, Mohammed, Moradiya, Hiren G., Halsey, Sheelagh, Bradley, Michael, Chowdhry, Babur, Snowden, Martin ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing. European Journal of Pharmaceutics and Biopharmaceutics, 96. pp. 106-116. ISSN 0939-6411 (Print), 1873-3441 (Online) (doi:https://doi.org/10.1016/j.ejpb.2015.06.021)

Inorganic excipients; Solid dispersions; Continuous extrusion

Maniruzzaman, M., Nair, A., Scoutaris, N., Bradley, Michael S.A., Snowden, M.J. ORCID: 0000-0002-1087-2692 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2015) One-step continuous extrusion process for the manufacturing of solid dispersions. International Journal of Pharmaceutics Special Issue on "Continuous Manufacturing and Process Analytical Tools”, 496 (1). pp. 42-51. ISSN 0378-5173 (Print), 1873-3476 (Online) (doi:https://doi.org/10.1016/j.ijpharm.2015.09.048)

Solid, Dispersions, Surface, Analysis

Maniruzzaman, Mohammed, Snowden, Martin ORCID: 0000-0002-1087-2692 , Bradley, Michael and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2015) Correction: Studies of intermolecular interactions in solid dispersions using advanced surface chemical analysis. RSC Advances, 5 (103). p. 84936. ISSN 2046-2069 (Online) (doi:https://doi.org/10.1039/c5ra90091c)

Wet granulation; DoE; QbD; Dissolution rate; Specific surface area; Water sorption

Maniruzzaman, Mohammed, Ross, Steven A., Dey, Tumpa, Nair, Arun, Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2017) A quality by design (QbD) twin–screw extrusion wet granulation approach for processing water insoluble drugs. International Journal of Pharmaceutics, 526 (1-2). pp. 496-505. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2017.05.020)

additives, crystallization, engineered xylitol, indomethacin, tableting

Kaialy, Waseem, Maniruzzaman, Mohammad, Shojaee, Saeed and Nokhodchi, Ali (2014) Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance. International Journal of Pharmaceutics, 477 (1-2). pp. 282-293. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2014.10.015)

advanced surface chemical analysis; drug/polymer interactions

Maniruzzaman, Mohammed, Snowden, Martin ORCID: 0000-0002-1087-2692 , Bradley, Michael and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2015) Studies of intermolecular interactions in solid dispersions using advanced surface chemical analysis. RSC Advances: An international journal to further the chemical sciences, 5 (91). pp. 74212-74219. ISSN 2046-2069 (Online) (doi:https://doi.org/10.1039/C5RA13176F)

continuous cocrystallisation, carbamazepine, trans-cinnamic acid, melt extrusion processing

Moradiya, Hiren G., Islam, Muhammad T., Halsey, Sheelagh, Maniruzzaman, Mohammed, Chowdhry, Babur Z., Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, D. ORCID: 0000-0002-3782-0091 (2014) Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing. CrystEngComm, 16 (17). pp. 3573-3583. ISSN 1466-8033 (doi:https://doi.org/10.1039/c3ce42457j)

e-tongue, hot-melt extrusion, molecular dispersions, taste masking

Maniruzzaman, Mohammed, Bonnefille, Marion, Aranyos, Attila, Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2013) An in-vivo and in-vitro taste masking evaluation of bitter melt-extruded drugs. Journal of Pharmacy and Pharmacology, 66 (2). pp. 323-337. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:https://doi.org/10.1111/jphp.12169)

extrusion, lipids, solid dispersions, tablet, solid dosage form

Vithani, K., Maniruzzaman, M., Slipper, I.J., Mostafa, S., Miolane, C., Cuppok, Y., Marchaud, D. and Douroumis, D. ORCID: 0000-0002-3782-0091 (2013) Sustained release solid lipid matrices processed by hot-melt extrusion (HME). Colloids and Surfaces B: Biointerfaces, 110. pp. 403-410. ISSN 0927-7765 (doi:https://doi.org/10.1016/j.colsurfb.2013.03.060)

hot-melt extrusion, in-line NIR, process analytical technology, quality by design, critical quality attributes

Islam, Muhammad T., Maniruzzaman, Mohammed, Halsey, Sheelagh A., Chowdhry, Babur Z. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2014) Development of sustained-release formulations processed by hot-melt extrusion by using a quality-by-design approach. Drug Delivery and Translational Research, 4 (4). pp. 377-387. ISSN 2190-393X (Print), 2190-3948 (Online) (doi:https://doi.org/10.1007/s13346-014-0197-8)

hot-melt extrusion, taste masking, electronic tongue, solubility parameter

Maniruzzaman, Mohammed, Boateng, Joshua S. ORCID: 0000-0002-6310-729X , Bonnefille, Marion, Arranyos, Attila, Mitchell, John C. ORCID: 0000-0003-2945-3292 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2011) Taste masking of paracetamol by hot-melt extrusion: An in vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 80 (2). pp. 433-442. ISSN 0939-6411 (doi:https://doi.org/10.1016/j.ejpb.2011.10.019)

hot-melt extrusion, taste masking, orally disintegrating tablets, Eudragit EPO

Gryczke, Andreas, Schminke, Silke, Maniruzzaman, Mohammed, Beck, Julien and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2011) Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. Colloids and Surfaces B: Biointerfaces, 86 (2). pp. 275-284. ISSN 0927-7765 (doi:https://doi.org/10.1016/j.colsurfb.2011.04.007)

mesoporous silica, functionalized silica nanoparticles, cellular uptake, toxicity, drug delivery, imaging

Douroumis, Dionysios ORCID: 0000-0002-3782-0091 , Onyesom, Ichioma, Maniruzzaman, Mohammed and Edwards, Mark (2011) Mesoporous silica nanoparticles as a drug delivery system. In: Vivero-Escoto, Juan, (ed.) Silica Nanoparticles: Preparation, Properties and Uses. Nanotechnology Science and Technology Series. Chemical Engineering Methods and Technology Series . Nova Science Publishers, Hauppauge, NY, USA, pp. 81-114. ISBN 978-1-61324-452-4

polymorphs, transformation, variable-temperature XRPD, caprolactam, extrudates, near-infrared spectroscopy, Polynorphism, drug delivery, crystals

Maniruzzaman, Mohammed, Islam, Muhammad T., Moradiya, Hiren G., Halsey, Sheelagh A., Slipper, Ian J., Chowdhry, Babur Z., Snowden, Martin J. ORCID: 0000-0002-1087-2692 and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2014) Prediction of polymorphic transformations of paracetamol in solid dispersions. Journal of Pharmaceutical Sciences, 103 (6). pp. 1819-1828. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:https://doi.org/10.1002/jps.23992)

solid dispersions, quantum mechanics, molecular modelling, miscibility, drug-polymer interactions

Maniruzzaman, Mohammed, Pang, Jiayun ORCID: 0000-0003-0689-8440 , Morgan, David J. and Douroumis, Dennis ORCID: 0000-0002-3782-0091 (2015) Molecular modelling as a predictive tool for the development of solid dispersions. Molecular Pharmaceutics, 12 (4). pp. 1040-1049. ISSN 1543-8384 (Print), 1543-8392 (Online) (doi:https://doi.org/10.1021/mp500510m)