computational studies support, C7-sibirosamine sugar, pyrrolobenzodiazepine (PBD) sibiromycin, transcription factor inhibition

Jackson, Paul J. M., James, Colin H., Jenkins, Terence C., Rahman, Khondaker C. and Thurston, David E. (2014) Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition. ACS Chemical Biology, 9 (10). pp. 2432-2440. ISSN 1554-8929 (Print), 1554-8937 (Online) (doi:10.1021/cb5002203)

pyrrolobenzodiazepine (PBD)-conjugate, inverted CCAAT box, nuclear factor Y, topoisomerase IIa, nticancer agents

Brucoli, Federico, Hawkins, Rachel M., James, Colin H., Wells, Geoff, Jenkins, Terrence C., Ellis, Tom, Hartley, John A., Howard, Philip W. and Thurston, David E. (2011) Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box. Bioorganic & Medicinal Chemistry Letters, 21. pp. 3780-3783. ISSN 0960-894X (online) (doi:10.1016/j.bmcl.2011.04.054)

voltage-gated sodium channels, BW202W92, BW203W92, X-ray crystallographic structures

Palmer, Rex A., Potter, Brian S., Leach, Michael J. ORCID: https://orcid.org/0000-0002-9859-1325, Jenkins, Terence C. and Chowdhry, Babur Z. (2010) An absolute structure template for a unique voltage-gated sodium channel binding site. MedChemComm, 1 (1). pp. 45-49. ISSN 2040-2503 (Print), 2040-2511 (Online) (doi:10.1039/C0MD00043D)