Cytokines, treatment of multiple sclerosis

BTG International Limited (2006) Treatment of cytokine dysregulation by using sn-2 gamma-linolenoyl, gamma-dihomolinolenoyl or arachidonoyl patty acid glycerol monoesters. WO2006/092622A1.

Ghrelin expression, effect of exercise, obesity

Xiang, M., Liu, W., Harbige, L.S. and Ai, H. (2011) Ghrelin expression and effect of exercise in obesity. Proceedings of the Nutrition Society, 70 (OCE2). E45-E45. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665111000760)

In vitro model, Spreading, Leishmania aethiopica, Leishmania mexicana, Human monocytes, Infection, THP-1, Retinoic acid

Rai, Rajeev, Dyer, Paul, Richardson, Simon ORCID: https://orcid.org/0000-0002-7927-0649, Harbige, Laurence and Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496 (2017) Apoptotic induction induces Leishmania aethiopica and L. mexicana spreading in terminally differentiated THP-1 cells. Parasitology, 144 (14). pp. 1912-1921. ISSN 0031-1820 (Print), 1469-8161 (Online) (doi:10.1017/S0031182017001366)

Kazakhstan, Sweden, breast-milk, nutrition, infants

Xiang, Mingyan, Harbige, Laurence S. and Zetterström, Rolf (2008) Breast-milk levels of long-chain PUFA in Kazakhstan and Sweden. Proceedings of the Nutrition Society, 67 (OCE1). E79-E79. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665108006885)

Multiple sclerosis, polyunsaturated fatty acids

BTG International Limited (2010) Cytokine modulators using cyclic glycerides of essential polyunsaturated fatty acids. PT1853254 (E).

Omega-6 fatty acids, gene expression

Harbige, Laurence (2009) Modulation by Omega-6 fatty acids of gene expression, immune functions and immune-inflammatory disorders. In: 3rd International Immunonutrition Workshop, 21-24 Oct 2009, Platja d’Aro, Girona, Spain. (Unpublished)

Polyunsaturated fatty acids, neurodegenerative diseases

BTG International Limited (2006) Treatment of cytokine dysregulation by using sn-2 gamma-linolenoyl, gamma-dihomolinolenoyl or arachidonoyl patty acid glycerol monoesters. PCT/GB2006/000778.

Polyunsaturated fatty acids, treatment of multiple sclerosis

BTG International Limited (2004) Use of triglyceride oils containing gamma-linolenic residues and linoleic acid residues for the treatment of neurodegenerative disease. WO2004/100943 A1.

Treatment of multiple sclerosis

BTG International Limited (2005) Treatment of neurodegenerative conditions. WO2005/018632/A1.

Visfatin, obesity, weight loss

Xiao, H., Xiang, M., Harbige, L.S. and Ai, H. (2011) Visfatin as a novel adipokine in relation to AMP-activated protein kinase in obesity and weight loss. Proceedings of the Nutrition Society, 70 (OCE2). E46-E46. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665111000772)

Yakult, milk drinks, L. casei Shirota, saliva, IFN-y, sIgA, IgA1 and IgA2, pilot studies

O'Connell, E., Allgrove, J., Pollard, L., Xiang, M. and Harbige, L. S. (2009) A pilot study investigating the effects of Yakult fermented milk drink (L. casei Shirota) on salivary IFN-y, sIgA, IgA1 and IgA2 in healthy volunteers. In: The 5th International Yakult Symposium: The Gut and More, Probiotic Influences Beyond the Gut, 18 - 19 Jun 2009, St. Olofskapel, Barbizon Palace Hotel, Amsterdam, The Netherlands. (Unpublished)

Yakult, milk drinks,(L. casei Shirota), saliva, IFN-, sIgA, IgA1 and IgA2, pilot studies

O'Connell, Elisabeth J., Allgrove, Judith E., Pollard, Lucie V., Xiang, Mingyan and Harbige, Laurence S. (2010) A pilot study investigating the effects of Yakult fermented milk drink (L. casei Shirota) on salivary IFN-y, sIgA, IgA1 and IgA2 in healthy volunteers. Proceedings of the Nutrition Society, 69 (OCE3). E267-E267. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S002966511000056X)

arachidonic acid, balance, breast milk, Chinese and Swedish infants, docosahexaenoic acid, growth, long-chain polyunsaturated fatty acids

Xiang, Mingyan, Harbige, Laurence S. and Zetterström, Rolf (2005) Long-chain polyunsaturated fatty acids in Chinese and Swedish mothers: diet, breast milk and infant growth. Acta Paediatrica, 94 (11). pp. 1543-1549. ISSN 0803-5253 (doi:10.1080/08035250500251601)

arachidonic acid, breast milk, Chinese infants, growth, omega-6 polyunsaturated fatty acids, zinc

Xiang, Mingyan, Harbige, Laurence S. and Zetterström, Rolf (2007) Breast milk levels of zinc and omega-6 polyunsaturated fatty acids and growth of healthy Chinese infants. Acta Paediatrica, 96 (3). pp. 387-390. ISSN 0803-5253 (doi:10.1111/j.1651-2227.2006.00140.x)

benzodiazepine, cutaneous leishmaniasis

Parbhu Patel, Asha, Deacon, Andrew D., Spencer, John, Raj, Rathnam, Harbige, Laurence and Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496 (2010) The benzodiazepine class of compounds as a potential for the treatment of cutaneous leishmaniasis. In: XII International Congress of Parasitology ICOPA, 15 - 20 Aug 2010, Melbourne, Australia. (Unpublished)

borage, gamma-linolneic acid, GLA, monocyte chemoattractant protein 1, chronic inflammatory disease

Xiang, M., Pinto, E., Rahman, M.A., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Harbige, L.S. (2008) Borage (Borago officinalis) oil supplementation in relation to monocyte chemoattractant protein 1 expression in healthy subjects. Proceedings of the Nutrition Society, 67 (OCE1). E44-E44. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665108006538)

borage, gamma-linolneic acid, GLA, monocyte, T-cells, inflammatory disease

Pinto, Eva and Harbige, Laurence S. (2008) Effects of borage (Borago officinalis) oil supplementation on the expression of monocyte and T-cell adhesion molecules in healthy volunteers. Proceedings of the Nutrition Society, 67 (OCE1). E63-E63. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665108006721)

creatine

Li, Bin, Xiang, Mingyan, Harbige, Laurence S., Li, Xian and Ai, Hua (2008) Effect of different doses of creatine supplementation on endogenous creatine synthesis. Proceedings of the Nutrition Society, 67 (OCE1). E48. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665108006575)

Li, X., Xiang, M., Harbige, L.S. and Ai, H. (2008) Effect of cessation of creatine supplementation on endogenous creatine synthesis. Proceedings of the Nutrition Society, 67 (OCE1). E49. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665108006587)

Xiang, M., Harbige, L.S., Li, X., Li, B. and Ai, H. (2008) Time-course study of high-dose creatine supplementation for endogenous creatine synthesis. Proceedings of the Nutrition Society, 67 (OCE1). E80. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665108006897)

dietary fat intake, gene expression, delta-6, delta-5, desaturases

Xiang, Mingyan, Rahman, Mohammed, Ai, H., Li, X and Harbige, L.S. (2006) Relationship between dietary fat intake and gene expression of delta-6 and delta-5 desaturases. In: 7th Congress of the ISSFAL, International Society for the Study of Fatty Acids & Lipids (ISSFAL 2006), 23–28 Jul 2006, Cairns, Queensland, Australia. (Unpublished)

fatty acids, carboxlyic acids, diet, genes

Xiang, Mingyan, Rahman, M. A., Ai, Hua, Li, Xian and Harbige, L. S. (2006) Diet and gene expression: delta-5 and delta-6-desaturases in healthy Chinese and European subjects. Annals of Nutrition and Metabolism, 50 (6). pp. 492-498. ISSN 0250-6807 (doi:10.1159/000095829)

fatty acids, pathogenesis, treatment, multiple sclerosis

Harbige, L. S., Hollifield, R. D., Pinto, E., Xiang, M., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Sharief, M. K. (2006) Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis. In: 7th Congress of the ISSFAL, International Society for the Study of Fatty Acids & Lipids (ISSFAL 2006), 23–28 July 2006, Cairns Convention Centre, Cairns, Queensland, Australia. (Unpublished)

fatty acids, w-6 fatty acid, chemokine, blood mononuclear cells, case studies

Pinto, E., Xiang, M., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Harbige, L.S. (2006) Effects of ω-6 fatty acid supplementation on chemokine production by peripheral blood mononuclear cells from healthy volunteers. In: 7th Congress of the ISSFAL, International Society for the Study of Fatty Acids & Lipids (ISSFAL 2006), 23–28 Jul 2006, Cairns, Queensland, Australia. (Unpublished)

Pinto, E. and Harbige, L.S. (2006) Effects of ω-6 fatty acids on human monocyte and T-cell adhesion molecule expression. In: 7th Congress of the ISSFAL, International Society for the Study of Fatty Acids & Lipids (ISSFAL 2006), 23–28 Jul 2006, Cairns, Queensland, Australia. (Unpublished)

gene expression, delta-6-desaturase, blood, Crohn's disease

Xiang, M., Al-Hassi, H.O., Harbige, L.S. and Knight, S.C. (2011) Gene expression of delta-6-desaturase in peripheral blood mononuclear cells, β7+ and β7 lymphocytes in healthy controls and patients with Crohn's disease. Proceedings of the Nutrition Society, 70 (OCE2). E44-E44. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665111000759)

high-dose creatine supplementation, endogenous creatine synthesis, exercise

Xiang, Mingyan, Harbige, Laurence S., Li, Bin, Li, Xian and Ai, Hua (2010) Effect of high-dose creatine supplementation on endogenous creatine synthesis during exercise. Proceedings of the Nutrition Society, 69 (OCE3). E321. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665110001102)

infant, allergy, diet, atopy

Loughrill, E., Harbige, L., Chowdhry, B.Z. and Zand, N. ORCID: https://orcid.org/0000-0003-2058-2354 (2013) The impact of early infant feeding on the development of atopic disease. Maternal & Child Nutrition, 9 (S3). pp. 48-49. ISSN 1740-8695 (Print), 1740-8709 (Online) (doi:10.1111/mcn.12094)

lamotrigine, multiple sclerosis, use patent

BTG International Limited (2004) Treatment of neurodegenerative conditions. US 2004/0229873 Al.

leptin, TNFα, obese, non-obese, United Kingdom

Chaidas, M. and Harbige, L.S. (2011) Relationship between circulating leptin and TNFα in obese and non-obese human subjects in the UK. Proceedings of the Nutrition Society, 70 (OCE2). E30-E30. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665111000619)

loading dose, maintenance dose, creatine, endogenous creatine synthesis, exercise

Li, Li, Li, Xian, Xiang, Mingyan, Harbige, Laurence S. and Ai, Hua (2010) Influence of two stages (loading dose and maintenance dose) creatine supplementation on endogenous creatine synthesis during heavy-load exercise. Proceedings of the Nutrition Society, 69 (OCE3). E323-E323. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665110001126)

low-dose creatine supplementation, endogenous creatine synthesis, exercise

Li, X., Xiang, M., Harbige, L.S., Meng, P.X. and Ai, H. (2010) Study of low-dose creatine supplementation for endogenous creatine synthesis during heavy-load exercise. Proceedings of the Nutrition Society, 69 (OCE3). E322-E322. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665110001114)

monocyte chemoattractant protein 1, 15-deoxy-12,14-prostaglandin J2, gamma-linolenic acid

Xiang, M., Pinto, E., Rahman, M.A., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Harbige, L.S. (2010) Decreased monocyte chemoattractant protein 1 and relationship with 15-deoxy-delta 12,14- prostaglandin J2 in gamma-linolenic acid supplemented healthy subjects. Proceedings of the Nutrition Society, 69 (OCE3). E325-E325. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S002966511000114X)

multiple sclerosis, MS, borage, BGC20-884

Harbige, L.S., Pinto, E., Xiang, M., Leach, M. ORCID: https://orcid.org/0000-0002-9859-1325 and Sharief, M. K. (2008) PUFA in the pathogenesis and treatment of patients with multiple sclerosis. Proceedings of the Nutrition Society, 67 (OCE1). E21. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665108006307)

multiple sclerosis, central nervous system, neurodegeneration

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. EP2324828 (A1).

multiple sclerosis, linoleic acid, gamma-linolenic acid, arachidonic acid, clinical trials, cytokines

Harbige, Laurence S. and Sharief, Mohammad K. (2007) Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis. British Journal of Nutrition, 98 (S1). S46-S53. ISSN 0007-1145 (doi:10.1017/S0007114507833010)

multiple sclerosis, neurodegeneration, central nervous system

BTG International Ltd. (2011) Treatment of neurodegenerative conditions. JP2011144195.

phospholipids, treatment of multiple sclerosis

BTG International Limited (2006) Structured phospholipids. WO2006/056783 A2.

plasma cytokines, zinc, copper, vitamin A, vitamin E, multiple sclerosis patients

Harbige, L.S., Pinto, E., Xiang, M. and Shareif, M.K. (2011) Circulating plasma cytokines, zinc, copper, vitamins A and E in multiple sclerosis patients and healthy controls. Proceedings of the Nutrition Society, 70 (OCE2). E36-E36. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S002966511100067X)

polyunsaturated fatty acids, treatment of multiple sclerosis

BTG International Ltd (2010) Treatment of neurodegenerative conditions. US2010/0113810 A1.

schoolchildren, diet, learning, behaviour

Ells, Louisa J., Hillier, Frances C., Shucksmith, Janet, Crawley, Helen, Harbige, Laurence, Shield, Julian, Wiggins, Andy and Summerbell, Carolyn D. (2008) A systematic review of the effect of dietary exposure that could be achieved through normal dietary intake on learning and performance of school-aged children of relevance to UK schools. British Journal of Nutrition, 100 (5). pp. 927-936. ISSN 0007-1145 (Print), 1475-2662 (Online) (doi:10.1017/S0007114508957998)

structured phospholipids, cytokines, multiple sclerosis

BTG International Ltd (2009) Structured phospholipids. US2009/0036410 A1.

triazines, medical use

University of Greenwich, Old Royal Naval College Park Row, Greenwich, London SE10 9LS (2008) New medical use of triazine derivatives. WO/2008/007149.

triazines, sodium channel blockers

University of Greenwich, Old Royal Naval College Park Row, Greenwich London SE10 9LS (2009) Cyclic triazo and diazo sodium channel blockers. WO/2009/090431.

triazines, sodium channel blockers, central nervous system diseases

University of Greenwich (2010) Cyclic triazo sodium channel blockers. 12801937.

triglycerides, neurodegenerative diseases, multiple sclerosis

BTG International Limited (2008) Treatment of neurodegenerative conditions. GB2442161/B.

visfatin, adipokine, AMP-activated protein kinase, obesity

Xiao, H., Xiang, M., Harbige, L.S. and Ai, H. (2010) Relation between visfatin as a novel adipokine and AMP-activated protein kinase in obesity. Proceedings of the Nutrition Society, 69 (OCE3). E324-E324. ISSN 0029-6651 (Print), 1475-2719 (Online) (doi:10.1017/S0029665110001138)

zinc, w-6 polyunsaturated fatty acids, maternal milk, child growth

Xiang, M., Harbige, L.S. and Zetterström, R. (2006) Relationship between zinc and ω-6 polyunsaturated fatty acids in breast milk and infant growth. In: 7th Congress of the ISSFAL, International Society for the Study of Fatty Acids & Lipids (ISSFAL 2006), 23–28 Jul 2006, Cairns, Queensland, Australia. (Unpublished)