Article

Veeravalli, Sunil, Varshavi, Dorsa, Scott, Flora H, Varshavi, Dorna, Pullen, Francis, Veselkov, Kirill, Phillips, Ian R, Everett, Jeremy ORCID: 0000-0003-1550-4482 and Shephard, Elizabeth (2022) Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5-/- mice, decreases plasma cholesterol and epididymal fat deposition. Frontiers in Physiology, 13:859681. pp. 1-13. ISSN 1664-042X (Online) (doi:https://doi.org/10.3389/fphys.2022.859681)

Varshavi, Dorna, Varshavi, Dorsa, McCarthy, Nicola, Veselkov, Kirill, Keun, Hector C. and Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2021) Metabonomics study of the effects of single copy mutant KRAS in the presence or absence of WT allele using human HCT116 isogenic cell lines. Metabolomics, 17 (12):104. ISSN 1573-3882 (Print), 1573-3890 (Online) (doi:https://doi.org/10.1007/s11306-021-01852-w)

Varshavi, Dorna, Varshavi, Dorsa, Veselkov, Kirill, McCarthy, Nicola, Keun, Hector C. and Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2020) Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines. Metabolomics, 16 (4):51. ISSN 1573-3882 (Print), 1573-3890 (Online) (doi:https://doi.org/10.1007/s11306-020-01674-2)

Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy R. ORCID: 0000-0003-1550-4482 and Shephard, Elizabeth A. (2020) Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. Drug Metabolism and Disposition, 48 (4). ISSN 0090-9556 (Print), 1521-009X (Online) (doi:https://doi.org/10.1124/dmd.119.089995)

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 , Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. and Nicholson, Jeremy K. (2019) A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Trends in Pharmacological Sciences, 40 (10). pp. 763-773. ISSN 0165-6147 (Print), 1873-3735 (Online) (doi:https://doi.org/10.1016/j.tips.2019.08.004)

Scott, Flora H., Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A. and Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2018) Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers in Molecular Biosciences, 5:28. ISSN 2296-889X (Online) (doi:https://doi.org/10.3389/fmolb.2018.00028)

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2017) NMR-based pharmacometabonomics: A new paradigm for personalised or precision medicine. Progress in Nuclear Magnetic Resonance Spectroscopy, 102-3. pp. 1-14. ISSN 0079-6565 (Print), 1873-3301 (Online) (doi:https://doi.org/10.1016/j.pnmrs.2017.04.003)

Varshavi, Dorsa, Varshavi, Dorna and Everett, Jeremy ORCID: 0000-0003-1550-4482 (2016) The role of pharmacometabonomics in predicting drug pharmacokinetics. International Journal of Pharmacokinetics, 1 (1). pp. 5-8. ISSN 2053-0846 (Print), 2053-0854 (Online) (doi:https://doi.org/10.4155/ipk-2016-0010)

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2016) From metabonomics to pharmacometabonomics: The role of metabolic profiling in personalized medicine. Frontiers in Pharmacology, 7:297. ISSN 1663-9812 (doi:https://doi.org/10.3389/fphar.2016.00297)

Bell, Andrew S., Bradley, Joseph, Everett, Jeremy ORCID: 0000-0003-1550-4482 , Loesel, Jens, McLoughlin, David, Mills, James, Peakman, Marie-Claire, Sharp, Robert E., Williams, Christine and Zhu, Hongyao (2016) Plate-based diversity subset screening generation 2: An improved paradigm for high throughput screening of large compound files. Molecular Diversity, 20 (4). pp. 789-803. ISSN 1381-1991 (Print), 1573-501X (Online) (doi:https://doi.org/10.1007/s11030-016-9692-9)

Sanchon-Lopez, Beatriz and Everett, Jeremy ORCID: 0000-0003-1550-4482 (2016) New methodology for known metabolite identification in metabonomics / metabolomics: topological metabolite identification carbon efficiency (tMICE). Journal of Proteome Research, 15 (9). pp. 3405-3419. ISSN 1535-3893 (Print), 1535-3907 (Online) (doi:https://doi.org/10.1021/acs.jproteome.6b00631)

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 , Dona, Anthony C., Kyriakides, Michael, Scott, Flora, Shephard, Elizabeth A., Varshavi, Dorsa and Veselkov, Kirill (2016) A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments. Computational and Structural Biotechnology Journal, 14. pp. 135-153. ISSN 2001-0370 (Print), 2001-0370 (Online) (doi:https://doi.org/10.1016/j.csbj.2016.02.005)

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2015) Academic drug discovery: Current status and prospects. Expert Opinion on Drug Discovery, 10 (9). pp. 937-944. ISSN 1746-0441 (Print), 1746-045X (Online) (doi:https://doi.org/10.1517/17460441.2015.1059816)

Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy ORCID: 0000-0003-1550-4482 , Tsuchiya, Yugo, Timms, John F., Phillips, Ian R. and Shephard, Elizabeth A. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, 96 (3). pp. 267-277. ISSN 0006-2952 (doi:https://doi.org/10.1016/j.bcp.2015.05.013)

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2015) Pharmacometabonomics in humans: a new tool for personalized medicine. Pharmacogenomics, 16 (7). pp. 737-754. ISSN 1462-2416 (doi:https://doi.org/10.2217/PGS.15.20)

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2015) A new paradigm for known metabolite identification in metabonomics/metabolomics: Metabolite identification efficiency. Computational and Structural Biotechnology Journal, 13. pp. 131-144. ISSN 2001-0370 (doi:https://doi.org/10.1016/j.csbj.2015.01.002)

Everett, Jeremy ORCID: 0000-0003-1550-4482 , Loo, Ruey Leng and Pullen, Francis S. (2013) Pharmacometabonomics and personalized medicine. Annals of Clinical Biochemistry, 50 (6). pp. 523-545. ISSN 0004-5632 (Print), 1758-1001 (Online) (doi:https://doi.org/10.1177/0004563213497929)

Bell, Andrew S., Bradley, Joseph, Everett, Jeremy R. ORCID: 0000-0003-1550-4482 , Knight, Michelle, Loesel, Jens, Mathias, John, McLoughlin, David, Mills, James, Sharp, Robert E., Williams, Christine and Wood, Terence P. (2013) Plate-based diversity subset screening: an efficient paradigm for high throughput screening of a large screening file. Molecular Diversity, 17 (2). pp. 319-335. ISSN 1381-1991 (Print), 1573-501X (Online) (doi:https://doi.org/10.1007/s11030-013-9438-x)

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2013) Report on the 10th Anniversary of International Drug Discovery Science and Technology Conference, 8-10 November 2012, Nanjing, China. Expert Opinion on Drug Discovery, 8 (3). pp. 357-361. ISSN 1746-0441 (Print), 1746-045X (Online) (doi:https://doi.org/10.1517/17460441.2013.762353)

Bakken, Gregory A., Bell, Andrew S., Boehm, Markus, Everett, Jeremy R. ORCID: 0000-0003-1550-4482 , Gonzales, Rosalia, Hepworth, David, Klug-McLeod, Jacquelyn L., Lanfear, Jeremy, Loesel, Jens, Mathias, John and Wood, Terence P. (2012) Shaping a screening file for maximal lead discovery efficiency and effectiveness: elimination of molecular redundancy. Journal of Chemical Information and Modeling, 52 (11). pp. 2937-2949. ISSN 1549-9596 (Print), 1549-960X (Online) (doi:https://doi.org/10.1021/ci300372a)

Cunningham, Katharine, Claus, Sandrine P., Lindon, John C., Holmes, Elaine, Everett, Jeremy R. ORCID: 0000-0003-1550-4482 , Nicholson, Jeremy K. and Coen, Muireann (2012) Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response. Journal of Proteome Research, 11 (9). pp. 4630-4642. ISSN 1535-3893 (Print), 1535-3907 (Online) (doi:https://doi.org/10.1021/pr300430u)

Nicholson, Jeremy K., Everett, Jeremy R. ORCID: 0000-0003-1550-4482 and Lindon, John C. (2012) Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy. Expert Opinion on Drug Metabolism & Toxicology, 8 (2). pp. 135-139. ISSN 1742-5255 (doi:https://doi.org/10.1517/17425255.2012.646987)

Clayton, T. Andrew, Baker, David, Lindon, John C., Everett, Jeremy R. ORCID: 0000-0003-1550-4482 and Nicholson, Jeremy K. (2009) Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106 (34). pp. 14728-14733. ISSN 0027-8424 (Print), 1091-6490 (Online) (doi:https://doi.org/10.1073/pnas.0904489106)

Clayton, T. Andrew, Lindon, John C., Everett, Jeremy R. ORCID: 0000-0003-1550-4482 , Charuel, Claude, Hanton, Gilles, Le Net, Jean-Loic, Provost, Jean-Pierre and Nicholson, Jeremy K. (2006) Hepatotoxin-induced hypertyrosinemia and its toxicological significance. Archives of Toxicology, 81 (3). pp. 201-210. ISSN 0340-5761 (Print), 1432-0738 (Online) (doi:https://doi.org/10.1007/s00204-006-0136-7)

Clayton, T. Andrew, Lindon, John C., Cloarec, Olivier, Antti, Henrik, Charuel, Claude, Hanton, Gilles, Provost, Jean-Pierre, Le Net, Jean-Loïc, Baker, David, Walley, Rosalind J., Everett, Jeremy R. ORCID: 0000-0003-1550-4482 and Nicholson, Jeremy K. (2006) Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature, 440 (7087). pp. 1073-1077. ISSN 0028-0836 (Print), 1476-4687 (Online) (doi:https://doi.org/10.1038/nature04648)

Yap, Ivan K.S., Clayton, T. Andrew, Tang, Huiru, Everett, Jeremy R. ORCID: 0000-0003-1550-4482 , Hanton, Gilles, Provost, Jean-Pierre, Le Net, Jean-Loic, Charuel, Claude, Lindon, John C. and Nicholson, Jeremy K. (2006) An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate. Journal of Proteome Research, 5 (10). pp. 2675-2684. ISSN 1535-3893 (Print), 1535-3907 (Online) (doi:https://doi.org/10.1021/pr0601584)

Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine and Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2000) Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts in Magnetic Resonance, 12 (5). pp. 289-320. ISSN 1552-5023 (online) (doi:https://doi.org/10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W)

Book Section

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2019) Pharmacometabonomics: the prediction of drug effects using metabolic profiling. In: Barrett, James E., Page, Clive P. and Michel, Martin C., (eds.) Concepts and Principles of Pharmacology: 100 Years of the Handbook of Experimental Pharmacology. Handbook of Experimental Pharmacology, 260 . Springer, Cham, Switzerland, pp. 263-300. ISBN 978-3030353612 (doi:https://doi.org/10.1007/164_2019_316)

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2018) Applications of metabolic phenotyping in pharmaceutical research and development. In: Lindon, John C., Nicholson, Jeremy K. and Holmes, Elaine, (eds.) The Handbook of Metabolic Phenotyping. Elsevier, pp. 407-448. ISBN 978-0128122938

Everett, Jeremy ORCID: 0000-0003-1550-4482 , Lindon, John and Nicholson, Jeremy (2016) Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. In: Nicholson, Jeremy, Darzi, A, Lindon, John and Holmes, Elaine, (eds.) Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, pp. 137-165. ISBN 9780128003442 (doi:https://doi.org/10.1016/B978-0-12-800344-2.00006-9)

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2015) NMR-based pharmacometabonomics: A new approach to personalised medicine. In: Everett, Jeremy ORCID: 0000-0003-1550-4482 , Harris, Robin, Lindon, John and Wilaon, Ian, (eds.) NMR in Pharmaceutical Sciences. eMagRes books, 4 . John Wiley & Sons Ltd, Chichester, UK, pp. 359-372. ISBN 9780470034590

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2015) Drug discovery and development: the role of NMR. eMagRes. John Wiley & Sons, Ltd., London, UK, pp. 137-150. ISBN 9780470034590 (doi:https://doi.org/10.1002/9780470034590.emrstm1389)

Everett, Jeremy R. ORCID: 0000-0003-1550-4482 (2006) Metabolic applications in clinical pharmaceutical R&D. In: Lindon, John C., Nicholson, Jeremy K. and Holmes, Elaine, (eds.) The Handbook of Metabonomics and Metabolomics. Elsevier, Amsterdam, The Netherlands, pp. 279-287. ISBN 9780444528414

Edited Book

Everett, Jeremy ORCID: 0000-0003-1550-4482 , Harris, Robin, Lindon, John and Wilson, Ian (eds.) (2015) NMR in pharmaceutical sciences. eMagRes Books . Wiley. ISBN 9781118997666

Conference or Conference Paper

Said, Mohamed, Thompson, Elinor ORCID: 0000-0002-6434-9290 and Everett, Jeremy ORCID: 0000-0003-1550-4482 (2021) Modulation of ageing by genetic knock-out, phototherapy and drugs in the C. elegans worm. In: Metabolism of Ageing, 06 - 08 Sep 2021, online. (Unpublished)

Said, Mohamed, Thompson, Elinor ORCID: 0000-0002-6434-9290 and Everett, Jeremy ORCID: 0000-0003-1550-4482 (2019) Metabolic ageing in the C. elegans worm and modulation by genetic knock-out, phototherapy and drugs. In: UK C.elegans meeting, 16th September 2019, Imperial College London, Sir Alexander Fleming Building, Imperial College Rd, London, UK. (Unpublished)

Everett, Jeremy ORCID: 0000-0003-1550-4482 and Sanchon Lopez, Beatriz (2016) New Approaches to NMR-Based Metabolite Identification. In: 12th Annual Conference of the Metabolomics Society, 27 June 2016 - 30 June 2016, Dublin, Eire.

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2015) From metabonomics to pharmacometabonomics: Mice, men and microbiota. In: Neuviemes Journees Scientifiques du Reseau Francais de Metabolomique et Fluxomique, 9 -11 June 2015, Lille, France. (Unpublished)

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2015) Pharmacogenomics and pharmacometabonomics for personalised medicine. In: FOCUS 2015: National Meeting of the Association for Clinical Biochemistry & Laboratory Medicine, 8-11 June 2015, Cardiff, Wales.

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2015) From metabonomics to pharmacometabonomics: An NMR-based excursion from metabolite profiling to precision medicine. In: Invited Lecture at Institute of Food Research, 19 March 2015, Institute of Food Research, Norwich, UK.

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2015) From metabonomics to pharmacometabonomics: Mice, men and m microbiota. In: University College London Spring Seminars, 25 February 2015, University College London, UK.

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2014) Pharmacometabonomics: An important new paradigm for precision medicine. In: Metabomeeting 2014, 10-12 Sep 2014, The Royal Institution, London, UK. (Unpublished)

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2014) Pharmacometabonomics: The ability to use pre-dose metabolite profiles to predict drug responses. In: EMBL Practical Course: Metabolomics Bioinformatics for Life Scientists, 17- 21 March, 2014, Hinxton Genome Campus, UK.

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2013) New approaches to personalised medicine via pharmacometabonomics. In: Lifescience R&D Big Data Leaders Forum, 3-5 Dec 2013, Basel, Switzerland.

Everett, Jeremy ORCID: 0000-0003-1550-4482 (2013) New approaches to the design of large screening files for lead discovery. In: Lifescience R&D Big Data Leaders Forum, 3-5 Dec 2013, Basel, Switzerland.

Patent

Everett, Jeremy, Varshavi, Dorsa, Shephard, Elizabeth, and Veeravalli, Sunil (2021) Patent - Treatment of obesity and related conditions. .