Bone-cartilage interface, SAXS, strain

Riveiro Rodríguez, Antonio, Badar, Waqas, Ali, Husna ORCID: 0000-0003-3059-1262 , Brooker, Olivia N., Newham, Elis, Snow, Tim, Terrill, Nicholas J. ORCID: 0000-0002-8783-1282 , Tozzi, Gianluca, Fratzl, Peter, Knight, Martin M. and Gupta, Himadri S. ORCID: 0000-0003-2201-8933 (2022) Collagen pre-strain discontinuity at the bone—Cartilage interface. PLOS ONE, 17 (9). e0273832. ISSN 1932-6203 (doi:https://doi.org/10.1371/journal.pone.0273832)

X-ray tomography; musculoskeletal; biomaterials; digital volume correlation; in situ mechanics

Dall’Ara, E. ORCID: 0000-0003-1471-5077 , Bodey, A.J., Isaksson, H. and Tozzi, Gianluca (2022) A practical guide for in situ mechanical testing of musculoskeletal tissues using synchrotron tomography. Journal of the Mechanical Behavior of Biomedical Materials, 133:105297. pp. 1-13. ISSN 1751-6161 (doi:https://doi.org/10.1016/j.jmbbm.2022.105297)

anterior cruciate ligament (ACL); reconstruction; microcomputed tomography; biological modulation; demineralized bone matrix (DBM); bone marrow–derived mesenchymal stromal cell (BMSC) platelet-rich plasma (PRP)

Hexter, Adam T., Karali, Aikaterina, Kao, Alex, Tozzi, Gianluca, Heidari, Nima, Petrie, Aviva, Boyd, Ashleigh, Kalaskar, Deepak M., Pendegrass, Catherine, Rodeo, Scott, Haddad, Fares and Blunn, Gordon (2021) Effect of demineralized bone matrix, bone marrow mesenchymal stromal cells, and platelet-rich plasma on bone tunnel healing after anterior cruciate ligament reconstruction: a comparative micro-computed tomography study in a tendon allograft sheep model. Orthopaedic Journal of Sports Medicine, 9 (9). pp. 1-19. ISSN 2325-9671 (doi:https://doi.org/10.1177/23259671211034166)

bioinspired materials; biomaterials; biomineralization

Rumney, Robin M. H., Robson, Samuel C. ORCID: 0000-0001-5702-9160 , Kao, Alexander P., Barbu, Eugen, Bozycki, Lukasz, Smith, James R., Cragg, Simon M. ORCID: 0000-0003-1082-7653 , Couceiro, Fay, Parwani, Rachna, Tozzi, Gianluca, Stuer, Michael ORCID: 0000-0002-5937-0626 , Barber, Asa H., Ford, Alex T. ORCID: 0000-0001-5202-546X and Górecki, Dariusz C. ORCID: 0000-0003-3584-1654 (2022) Biomimetic generation of the strongest known biomaterial found in limpet tooth. Nature Communications, 13 (1):3753. pp. 1-13. ISSN 2041-1723 (Online) (doi:https://doi.org/10.1038/s41467-022-31139-0)

bone regeneration; biomaterials; micro finite element models; digital volume correlation; microdamage

Peña Fernández, Marta, Sasso, Sebastian J., McPhee, Samuel, Black, Cameron, Kanczler, Janos, Tozzi, Gianluca and Wolfram, Uwe (2022) Nonlinear micro finite element models based on digital volume correlation measurements predict early microdamage in newly formed bone. Journal of the Mechanical Behavior of Biomedical Materials, 132:105303. pp. 1-16. ISSN 1751-6161 (doi:https://doi.org/10.1016/j.jmbbm.2022.105303)

bone; AI; MLConvolutional; neural network; images; microCT; modeling

Shen, Sabrina Chin-yun ORCID: 0000-0002-6562-3829 , Peña Fernández, Marta, Tozzi, Gianluca and Buehler, Markus J. (2021) Deep learning approach to assess damage mechanics of bone tissue. Journal of the Mechanical Behavior of Biomedical Materials, 123:104761. ISSN 1751-6161 (doi:https://doi.org/10.1016/j.jmbbm.2021.104761)

bone; time-resolved SR-microCT; continuous in situ mechanics; digital volume correlation; time-dependent behaviour

Peña Fernández, Marta, Kao, Alexander P., Bonithon, Roxane, Howells, David, Bodey, Andrew J., Wanelik, Kazimir, Witte, Frank, Johnston, Richard, Arora, Hari and Tozzi, Gianluca (2021) Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation. Acta Biomaterialia, 131. pp. 424-439. ISSN 1742-7061 (Print), 1878-7568 (Online) (doi:https://doi.org/10.1016/j.actbio.2021.06.014)

digital volume correlation, musculoskeletal tissues, biomaterials, in situ mechanics, bone

Dall’Ara, Enrico and Tozzi, Gianluca (2022) Digital volume correlation for the characterization of musculoskeletal tissues: current challenges and future developments. Frontiers in Bioengineering and Biotechnology, 10:1010056. ISSN 2296-4185 (doi:https://doi.org/10.3389/fbioe.2022.1010056)

extracellular matrix; nanoclay; bone; 3D bioprinting

Kim, Yang-Hee, Kanczler, Janos M., Lanham, Stuart, Rawlings, Andrew, Roldo, Marta, Tozzi, Gianluca, Dawson, Jonathan I., Cidonio, Gianluca ORCID: 0000-0002-9445-6994 and Oreffo, Richard O. C. ORCID: 0000-0001-5995-6726 (2024) Biofabrication of nanocomposite-based scaffolds containing human bone extracellular matrix for the differentiation of skeletal stem and progenitor cells. Bio-Design and Manufacturing. ISSN 2096-5524 (Print), 2522-8552 (Online) (doi:https://doi.org/10.1007/s42242-023-00265-z)

hierarchical scaffolds; electrospinning; MicroCT; in situ mechanical tests; digital volume correlation; tendons and ligaments

Sensini, Alberto ORCID: 0000-0003-0681-5887 , Stamati, Olga ORCID: 0000-0002-7492-2134 , Marchiori, Gregorio ORCID: 0000-0002-2171-1851 , Sancisi, Nicola ORCID: 0000-0003-3005-6489 , Gotti, Carlo, Giavaresi, Gianluca, Cristofolini, Luca ORCID: 0000-0002-7473-6868 , Focarete, Maria Letizia, Zucchelli, Andrea ORCID: 0000-0002-3466-2913 and Tozzi, Gianluca (2024) Full-field strain distribution in hierarchical electrospun nanofibrous poly-L(lactic) acid/collagen scaffolds for tendon and ligament regeneration: a multiscale study. Heliyon, 10 (5):e26796. pp. 1-15. ISSN 2405-8440 (Online) (doi:https://doi.org/10.1016/j.heliyon.2024.e26796)

indentation; digital volume correlation (DVC); tissue irradiation; X-ray computed tomography (XCT); trabecular bone

Karali, Aikaterina ORCID: 0000-0003-4745-7123 , Dall’Ara, Enrico ORCID: 0000-0003-1471-5077 , Zekonyte, Jurgita, Kao, Alexander P., Blunn, Gordon and Tozzi, Gianluca (2022) Effect of radiation-induced damage of trabecular bone tissue evaluated using indentation and digital volume correlation. Journal of the Mechanical Behavior of Biomedical Materials, 138:105636. pp. 1-10. ISSN 1751-6161 (doi:https://doi.org/10.1016/j.jmbbm.2022.105636)

keloids; hypertrophic scarring; small-angle X-ray scattering; extracellular matrix; collagen fibrils; synchrotron X-ray imaging; digital image correlation; nanomechanics

Zhang, Yuezhou, Hollis, Dave, Ross, Rosie, Snow, Tim ORCID: 0000-0001-7146-6885 , Terrill, Nick J. ORCID: 0000-0002-8783-1282 , Lu, Yongjie, Wang, Wen, Connelly, John, Tozzi, Gianluca and Gupta, Himadri S. ORCID: 0000-0003-2201-8933 (2022) Investigating the fibrillar ultrastructure and mechanics in keloid scars using in situ synchrotron X-ray nanomechanical imaging. Materials, 15 (5):1836. pp. 1-19. ISSN 1996-1944 (doi:https://doi.org/10.3390/ma15051836)

magnesium alloys; bone regeneration; in situ mechanics; X-ray computed tomography (XCT); digital volume correlation (DVC); scanning electron microscopy (SEM); electron backscatter diffraction (EBSD); nanoindentation

Bonithon, Roxane ORCID: 0000-0002-4252-0894 , Kao, Alexander Peter ORCID: 0000-0001-5376-1661 , Fernández, Marta Peña ORCID: 0000-0002-3534-8838 , Dunlop, Joseph Nicholas, Blunn, Gordon William, Witte, Frank ORCID: 0000-0001-9154-6217 and Tozzi, Gianluca (2021) Multi-scale mechanical and morphological characterisation of sintered porous magnesium-based scaffolds for bone regeneration in critical-sized defects. Acta Biomaterialia, 127. pp. 338-352. ISSN 1742-7061 (Print), 1878-7568 (Online) (doi:https://doi.org/10.1016/j.actbio.2021.03.068)

magnesium alloys; bone regeneration; in vitro corrosion; X-ray computed tomography (XCT); digital volume correlation (DVC)

Bonithon, Roxane ORCID: 0000-0002-4252-0894 , Lupton, Colin ORCID: 0000-0001-8054-2712 , Roldo, Marta ORCID: 0000-0003-2242-7761 , Dunlop, Joseph Nicholas, Blunn, Gordon William, Witte, Frank ORCID: 0000-0001-9154-6217 and Tozzi, Gianluca (2022) Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading: a mechanistic study. Bioactive Materials, 19. pp. 406-417. ISSN 2452-199X (Online) (doi:https://doi.org/10.1016/j.bioactmat.2022.04.012)

nanoclay; InductOs®; bone morphogenic protein-2 (BMP-2); ovine; condyle defect

Black, Cameron, Gibbs, David, McEwan, Josephine, Kanczler, Janos ORCID: 0000-0001-7249-0414 , Fernández, Marta Peña ORCID: 0000-0002-3534-8838 , Tozzi, Gianluca, Dawson, Jonathan and Oreffo, Richard ORCID: 0000-0001-5995-6726 (2022) Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs®) in an ovine bone model. Journal of Tissue Engineering, 13. pp. 1-13. ISSN 2041-7314 (doi:https://doi.org/10.1177/20417314221113746)

polymeric scaffold; trabecular bone; mechanical properties; microCT; digital volume correlation

Rojas-Rojas, Laura ORCID: 0000-0002-1096-7659 , Tozzi, Gianluca and Guillén-Girón, Teodolito ORCID: 0000-0003-1823-3403 (2023) A comprehensive mechanical characterization of subject-specific 3D printed scaffolds mimicking trabecular bone architecture biomechanics. Life, 13 (11):2141. pp. 1-14. ISSN 2075-1729 (Online) (doi:https://doi.org/10.3390/life13112141)