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Innovative applications for insect viruses: towards insecticide sensitization

Innovative applications for insect viruses: towards insecticide sensitization

Lapied, Bruno, Pennetier, Cédric, Apaire-Marchais, Véronique, Licznar, Patricia and Corbel, Vincent (2009) Innovative applications for insect viruses: towards insecticide sensitization. Trends in Biotechnology, 27 (4). pp. 190-198. ISSN 0167-7799 (doi:https://doi.org/10.1016/j.tibtech.2008.12.005)

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Abstract

The effective management of emerging insect-borne disease is dependent on the use of safe and efficacious chemical insecticides. Given the inherent ability of insects to develop resistance, it is essential to propose innovative strategies because insecticides remain the most important element of integrated approaches to vector control. Recently, intracellular phosphorylation and dephosphorylation of membrane receptors and ion channels targeted by insecticides have been described as new processes for increasing the sensitivity of insecticides. An efficient method might be to infect host insects with recombinant viruses overexpressing specific protein phosphatases/kinases known to regulate specific insecticide-sensitive targets. This attractive strategy could lead to sensitization of the insects, thus reducing the doses of insecticides and increasing the efficacy of treatments.

Item Type: Article
Uncontrolled Keywords: insect-borne disease, insecticides, phosphorylation, dephosphorylation
Subjects: S Agriculture > S Agriculture (General)
S Agriculture > SB Plant culture
Faculty / Department / Research Group: Faculty of Engineering & Science > Natural Resources Institute
Related URLs:
Last Modified: 05 Oct 2012 14:13
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/9067

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