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Development of the custom polymeric materials specific for aflatoxin B1 and ochratoxin A for application with the ToxiQuant T1 sensor tool

Development of the custom polymeric materials specific for aflatoxin B1 and ochratoxin A for application with the ToxiQuant T1 sensor tool

Piletska, Elena, Karima, Kal, Coker, Raymond and Piletsky, Sergey (2009) Development of the custom polymeric materials specific for aflatoxin B1 and ochratoxin A for application with the ToxiQuant T1 sensor tool. Journal of Chromatography A, 1217 (16). pp. 2543-2547. ISSN 0021-9673 (doi:https://doi.org/10.1016/j.chroma.2009.11.091)

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Abstract

Two polymers were computationally designed with affinity to two of the most abundant mycotoxins aflatoxin B1 (AFB1) and ochratoxin A (OTA) for application in the ToxiQuant T1 System. The principle of quantification of AFB1 and OTA using the ToxiQuant T1 instrument comprised of a fluorimetric analysis of mycotoxins adsorbed on the polymer upon exposure to UV light. High affinity of the developed resins allowed the adsorption of both toxins as discrete bands on the top of the cartridge with detection limit as low as 1 ng quantity of mycotoxins.

Item Type: Article
Additional Information: [1] The Author's Accepted Manuscript is attached to this record. Please cite this article as: E. Piletska, K. Karim, R. Coker, S. Piletsky, Development of the custom polymeric materials specific for aflatoxin B1 and ochratoxin A for application with the ToxiQuant T1 sensor tool, Journal of Chromatography A (2008), doi:10.1016/j.chroma.2009.11.091 [2] Publisher's note: The Author's Accepted Manuscript is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. [3] Published in Journal of Chromatography A, Volume 1217, Issue 16, 16 April 2010 - Extraction Techniques. [4] Financial funding was provided by Toximet Ltd. for EP, KK and SP.
Uncontrolled Keywords: mycotoxins, aflatoxin B1, ochratoxin A, computational modelling, solid-phase extraction
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Faculty / Department / Research Group: Faculty of Engineering & Science > Natural Resources Institute
Related URLs:
Last Modified: 29 Apr 2016 04:55
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/7718

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