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Development and characterisation of sodium alginate and HPMC films for mucosal drug delivery

Development and characterisation of sodium alginate and HPMC films for mucosal drug delivery

Rai, Dinesh, Maniruzzaman, Mohammed and Boateng, Joshua S. ORCID: 0000-0002-6310-729X (2010) Development and characterisation of sodium alginate and HPMC films for mucosal drug delivery. International Journal of Biotechnology (IJBT), 11 (3/4). pp. 169-181. ISSN 0963-6048 (doi:https://doi.org/10.1504/IJBT.2010.036594)

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Abstract

The aim of this work was to develop and evaluate sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) films as novel drug delivery systems for moist surfaces such as wounds, buccal and vaginal cavities. Films containing SA or HPMC and PEG 200 or glycerol were prepared by a solvent casting technique. Process optimisation was performed to establish the best experimental parameters for preparing the films. Physical appearance, ease of removal, tensile properties (tensile strength, % strain at break) and plasticiser leaching were investigated. These criteria formed the basis for further development formulations comprising optimum ratios of SA/HPMC and PEG 200/glycerol. The optimum polymer-plasticiser combinations were then selected for further characterisation of tensile, hydration, adhesive properties by texture analysis and surface morphology by scanning electron microscopy. The
results showed the potential of developing both fast and controlled release mucosal formulations by a combination of the two polymers.

Item Type: Article
Uncontrolled Keywords: hydroxypropylmethylcellulose HPMC, sodium alginate SA, films, glycerol GLY, polyethylene glycol PEG, solvent casting, process optimisation
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 19 Oct 2016 10:20
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/7118

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