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Thermally stimulated current spectroscopy as a new tool in pharmaceutical materials science

Thermally stimulated current spectroscopy as a new tool in pharmaceutical materials science

Antonijević, Milan ORCID: 0000-0002-5847-7886 (2011) Thermally stimulated current spectroscopy as a new tool in pharmaceutical materials science. In: EUROanalysis 2011. 16th European Conference on Analytical Chemistry - "Challenges in Modern Analytical Chemistry", 11–15 Sep 2011, Belgrade, Serbia. (Unpublished)

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Recent developments in the pharmaceutical industry have led to an enormous increase in the variety of dosage forms available to the formulator. The stability of active compounds as well as the target site of the active material will govern the selection of the dosage form which is used in a given case. The design of pharmaceutical dosage forms requires not only a detailed knowledge of basic physical and chemical principles and states of aggregation, but also an understanding of the anomalies, transitions and interactions between different states of matter.

Although an extensive number of techniques provide important information about the phase transition processes and interactions between drugs and excipients, new/alternative techniques are also frequently being used to identify previously undetected transitions, interactions and reactions.

Thermally stimulated current (TSC) spectroscopy is a technique that monitors motions of molecular dipoles induced by the influence of static electrical field as sample is cooled or heated. Uniqueness of technique is in its ability to detect and characterise molecular motions at sub-ambient temperatures as well as to detect and characterise molecular mobility that cannot be detected by any other technique.

Majority of materials examined using TSC reveal additional information which was not previously reported in the literature but which may be of high importance in understanding the properties of materials, as well as their interactions with other molecules in pharmaceutical formulations.

Obtained results indicate that TSC is a useful tool for the detection and characterisation of glass transition processes, polymorphic transitions and other solid-state processes in pharmaceutical materials. Compared to other thermal techniques, TSC shows greater sensitivity, especially in the case of energetically weak transitions, and better resolution compared to dielectric analysis.

Ongoing research focuses on better understanding of molecular arrangements/interactions in co-crystals, their stability as well as prediction of drug excipient compatibility.

Item Type: Conference or Conference Paper (Paper)
Additional Information: [1] This paper was first presented at EUROanalysis 2011, 16th European Conference on Analytical Chemistry, "Challenges in Modern Analytical Chemistry", held from 11-15 September 2011 in Belgrade, Serbia. It was organized by the Divisions of Analytical Chemistry of the Serbian Chemical Society and the European Association for Chemical and Molecular Sciences. [1] The paper was given on 13 September 2011.
Uncontrolled Keywords: thermally stimulated current, polymorphs, amorphous
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science > School of Science (SCI)
Related URLs:
Last Modified: 17 Oct 2016 09:11

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