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Modelling and simulation of the behaviour of a biofluid in a microchannel biochip separator

Modelling and simulation of the behaviour of a biofluid in a microchannel biochip separator

Xue, Xiangdong, Patel, Mayur, Kersaudy-Kerhoas, Maïwenn, Bailey, Christopher and Desmulliez, Marc P.Y. (2011) Modelling and simulation of the behaviour of a biofluid in a microchannel biochip separator. Computer Methods in Biomechanics and Biomedical Engineering, 14 (6). pp. 549-560. ISSN 1025-5842 (Print), 1476-8259 (Online) (doi:https://doi.org/10.1080/10255842.2010.485570)

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Abstract

This paper reports an investigation into the flow behaviour of a biofluid in a microchannel systems through conceptual
analysis and modelling. The application is the design of a microfluidic chip developed for the separation of plasma from blood. The effect of key design features of the microchannels on the flow behaviour of the biofluid is explored. These include geometric features such as the constriction, bending channel, bifurcation and the channel length ratio between the main and side channels. The performance of each design is discussed in terms of separation efficiency of the red blood cells with respect to the rest of the medium. Particular phenomena such as the Fahraeus and Fahraeus–Lindqvist effects, the Zweifach–Fung bifurcation law and the cell-free layer are discussed. In this paper, the fluid is modelled as a single-phase
flow assuming either Newtonian or Non-Newtonian behaviour to investigate the effect of the fluid viscosity on both flow and separation efficiency. For a flow rate-controlled Newtonian flow system, it is found that viscosity and outlet pressure have little effect on the velocity distribution through each of the microchannels. For a diluted fluid where the flow in the whole channel system is modelled with a uniform viscosity, less plasma is separated from blood than observed in the non-Newtonian case. This results in an increase in the flow rate ratio between the main and side channels. A comparison of Newtonian and non-Newtonian flows shows that both flows tend to behave identically with an increase in the shear strain rate.

Item Type: Article
Uncontrolled Keywords: blood fluid separation, modelling and simulation, microfluidic device, microchannel device, cross-flow filtration
Subjects: R Medicine > R Medicine (General)
T Technology > TA Engineering (General). Civil engineering (General)
Faculty / Department / Research Group: Faculty of Architecture, Computing & Humanities
Related URLs:
Last Modified: 14 Oct 2016 09:17
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/6761

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