Skip navigation

Phenolics-rich extracts from Agarwood leaf-tea alleviate dextran sulfate sodium (DSS)-induced ulcerative colitis via modulating intestinal barrier function and gut microbiota

Phenolics-rich extracts from Agarwood leaf-tea alleviate dextran sulfate sodium (DSS)-induced ulcerative colitis via modulating intestinal barrier function and gut microbiota

Fan, Ruyan, Wei, Wensong ORCID logoORCID: https://orcid.org/0000-0001-5214-2973, Wei, Youjing, Lin, Xue, Zhou, Shaobo ORCID logoORCID: https://orcid.org/0000-0001-5214-2973 and Wang, Lu (2024) Phenolics-rich extracts from Agarwood leaf-tea alleviate dextran sulfate sodium (DSS)-induced ulcerative colitis via modulating intestinal barrier function and gut microbiota. Molecular Nutrition and Food Research. ISSN 1613-4125 (Print), 1613-4133 (Online) (In Press)

[thumbnail of Author's Accepted Manuscript] PDF (Author's Accepted Manuscript)
48620 ZHOU_Phenolics-Rich_Extracts_From_Agarwood_Leaf-Tea_Alleviate_Dextran_Sulfate_Sodium_DSS-Induced_Ulcerative_Colitis_(AAM)_2024.pdf - Accepted Version
Restricted to Repository staff only

Download (2MB) | Request a copy

Abstract

The increasing incidence of ulcerative colitis (UC) and the side effects of its therapeutic drugs have spurred the search for functional components derived from natural products as alternative treatments. This study investigated the effects of phenolics-rich extracts from Agarwood leaf tea (ALP) on alleviating dextran sulfate sodium (DSS)-induced colitis and explored its potential mechanisms. Results showed that ALP supplementation improved typical UC symptoms, reduced pro-inflammatory cytokines, and enhanced intestinal barrier function by promoting the expression of tight junction proteins Occludin and ZO-1 in colonic tissues. This repair of the intestinal barrier helped mitigate further tissue damage. Additionally, ALP effectively inhibited the NF-κB signaling pathway, leading to a decrease in pro-inflammatory cytokine release. ALP also modulated the gut microbiota in colitic mice, increasing beneficial bacteria (e.g., Parabacteroides, Chlamydia, Lachnospiraceae) and reducing harmful bacteria (e.g., Bactero

Item Type: Article
Uncontrolled Keywords: Agarwood leaf; ulcerative colitis; intestinal barrier; gut microbiota; NF-κB signaling pathway
Subjects: Q Science > Q Science (General)
Q Science > QK Botany
R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
Related URLs:
Last Modified: 15 Nov 2024 12:51
URI: http://gala.gre.ac.uk/id/eprint/48620

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics