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Ageing perspective on cognitive outcomes from auxiliary reproductive hormone adjustments

Ageing perspective on cognitive outcomes from auxiliary reproductive hormone adjustments

Zhang, Grace, Devo, Perry ORCID: 0000-0003-1487-8896 , O'Leary, Valerie B. ORCID: 0000-0003-1171-9830 and Ovsepian, Saak ORCID: 0000-0002-9522-4159 (2023) Ageing perspective on cognitive outcomes from auxiliary reproductive hormone adjustments. Heliyon, 9 (8):E19050. pp. 1-7. ISSN 2405-8440 (Online) (doi:

43738_OVSEPIAN_Ageing_perspective_on_cognitive_outcomes_from_auxiliary_reproductive_hormone_adjustments.pdf - Published Version
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In addition to primary reproductive functions, gonadal hormones play an important role in an array of neural mechanisms across the human lifespan. The ageing-related decline in their activity has been linked to the deterioration of cognitive functions in otherwise healthy women, associated with menopause transition, contributing to higher incidents of post-menopause dementia. Given the growing utility of gonadal steroids for birth control, as well as for compensatory treatment of menopause and oophorectomy symptoms, and adjuvant transgender therapy, their long-term effects on neural mechanisms warrant comprehensive assessment. In this article, we present an ageing perspective on the cognitive outcomes of contraceptive and replacement therapeutic use of gonadal hormones and discuss their effects on the risk of developing Alzheimer's and Parkinson's dementia. Despite rising data supporting the ameliorative effects of reproductive hormones on cognitive facilities, their impact varies depending on study design and type of intervention, thus, implying dynamic neuro-endocrine interactions with complex compensatory mechanisms. Elucidating differential effects of reproductive hormone adjustments on cognition with underlying mechanisms is expected not only to shed light on important aspects of brain ageing and dementia but to facilitate their use in personalized medicine with improved safety margins and therapeutic outcomes.

Item Type: Article
Additional Information: ** Article version: AM ** From Elsevier via Jisc Publications Router ** History: accepted 08-08-2023; issued 16-08-2023. ** Licence for AM version of this article starting on 08-08-2023:
Uncontrolled Keywords: neuroprotection; oestrogen; hormone replacement therapy; healthy ageing; contraception; gender transition; transgender; cognitive decline
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Q Science > QH Natural history > QH426 Genetics
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > School of Science (SCI)
SWORD Depositor: Users 6393 not found.
Last Modified: 23 May 2024 09:38

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