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Release of sodium fusidate from glass-ionomer dental cement

Release of sodium fusidate from glass-ionomer dental cement

Mulla, Zoheb, Edwards, Mark and Nicholson, John W. (2010) Release of sodium fusidate from glass-ionomer dental cement. Journal of Materials Science: Materials in Medicine, 21 (6). pp. 1997-2000. ISSN 0957-4530 (Print), 1573-4838 (Online) (doi:https://doi.org/10.1007/s10856-010-4060-2)

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Abstract

Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound sodium fusidate. Sodium fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter 9 2 mm depth)prepared. After curing for 1 hour at 37 deg C, specimens were placed in water and release of sodium fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of sodium fusidate was shown to occur by diffusion for each level of addition, as shown by Mt/M infinity being linear with respect to Htime in both cases. Diffusion coefficients were calculated as 4.4 9 10-8 cm2 s-1 and 3.0 9 10-8 cm2 s-1 for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the sodium fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total sodium fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine.

Item Type: Article
Uncontrolled Keywords: glass ionomers, sodium fusidate, controlled release
Subjects: R Medicine > RK Dentistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
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Last Modified: 17 Oct 2016 09:10
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/4342

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