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Investigation of the potential of the dissolution dynamic nuclear polarization method for general sensitivity enhancement in small-molecule NMR spectroscopy

Investigation of the potential of the dissolution dynamic nuclear polarization method for general sensitivity enhancement in small-molecule NMR spectroscopy

Day, I.J., Mitchell, J.C. ORCID: 0000-0003-2945-3292, Snowden, M.J. and Davis, A.L. (2008) Investigation of the potential of the dissolution dynamic nuclear polarization method for general sensitivity enhancement in small-molecule NMR spectroscopy. Applied Magnetic Resonance, 34 (3-4). pp. 453-460. ISSN 0937-9347 (Print), 1613-7507 (Online) (doi:https://doi.org/10.1007/s00723-008-0122-8)

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Abstract

We report results of applying a commercial implementation of the dissolution dynamic nuclear polarization (DNP) methodology developed by K. G. Golman et al. to a range of molecular species in the mass range of 100-400 Da. The molecules are typical of those that might be encountered in natural product chemistry or pharmaceutical analysis. Using an experimental protocol previously reported, in combination with the ERETIC method for generating a reference signal for estimation of concentrations, we determine the signal enhancement and high-field, liquid-state T-1 values for many of the carbon atoms in the six species studied. The results presented in this work suggest that the measured variation in nuclear magnetic resonance enhancements within a given molecule, arising from the dissolution DNP method, is accounted for principally by relaxation of C-13 atoms towards thermal polarization values in the liquid state. We conclude that dissolution DNP will be able to be employed for a wide range of chemical species, provided that the total time taken for dissolution and transfer of solutions is comparable to, or shorter than, the high-field, liquid-state T-1 values in the species being studied.

Item Type: Article
Additional Information: [1] Published in print: August 2008. [2] Published in Applied Magnetic Resonance (2008), Volume 34, Numbers 3-4, pp. 453-460. [3] This is issue is entitled "Dynamic Nuclear Polarization: New Experimental and Methodology Approaches and Applications in Physics, Chemistry, Biology and Medicine."
Uncontrolled Keywords: dissolution, dynamic nuclear polarization method, acquisition, relaxation, spectra, times
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Pre-2014 Departments: School of Science
Related URLs:
Last Modified: 14 Oct 2016 09:10
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
Selected for GREAT 2019: None
URI: http://gala.gre.ac.uk/id/eprint/4157

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