Kiaku, Cyrille, Walsh, Jamie M., Leech, Matthew C., Poole, Darren L., Mason, Joseph, Goodall, Iain C. A., Devo, Perry and Lam, Kevin ORCID: 0000-0003-1481-9212 (2023) eFluorination using cheap and readily available tetrafluoroborate salts. Organic Letters, 25 (9). pp. 1353-1358. ISSN 1523-7060 (Print), 1523-7052 (Online) (doi:https://doi.org/10.1021/acs.orglett.2c04305)

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Abstract

A practical electrochemical method for the rapid, safer, and mild synthesis of tertiary hindered alkyl fluorides from carboxylic acids has been developed without the need for hydrofluoric acid salts or non-glass reactors. In this anodic fluorination, collidinium tetrafluoroborate acts as both the supporting electrolyte and fluoride donor. A wide range of functional groups has been shown to be compatible, and the possibility of scale-up using flow electrochemistry has also been demonstrated.

Item Type:	Article
Uncontrolled Keywords:	Fluorine; electrosynthesis; Kolbe; anodic oxidation
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	02 Mar 2024 01:38
URI:	http://gala.gre.ac.uk/id/eprint/38717

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