Maklad, Osama ORCID: 0000-0001-6893-2654 (2023) Influence of fluid–structure interaction on human corneal biomechanics under air puff non-contact tonometry. In: Gunther, Paul and Doweidar, Mohamed Hamdy, (eds.) Digital Human Modeling and Medicine (The Digital Twin). Academic Press . Elsevier, London; San Diego; Cambridge; Oxford, pp. 465-490. ISBN 978-0128239131; 0128239131; (doi:https://doi.org/10.1016/C2020-0-00626-2)

	PDF (Accepted and corrected proof text) 38491_MAKLAD_ Influence_of_fluid_structure_interaction_on_human_corneal_biomechanics.pdf - Accepted Version Restricted to Repository staff only Download (1MB) | Request a copy
	PDF (Abstract) 38491_MAKLAD_ Influence_of_fluid_structure_interaction_on_human_corneal_biomechanics_ABSTRACT.pdf - Other Restricted to Repository staff only Download (68kB) | Request a copy

Abstract

This chapter presents a novel multiphysics fluid–structure interaction model of the noncontact air puff tonometry test using arbitrary Lagrangian–Eulerian deforming mesh in the coupling between computational fluid dynamics model of the air puff and finite element model of the human eye. The air puff test model was employed in a parametric numerical study simulating human eyes under air puff pressure with a wide range of central corneal thickness (CCT = 445–645 μm), curvature (R = 7.4–8.4 mm), material stiffness coefficient (μ = 0.0422–0.1082), and intraocular pressure (IOP = 10–25 mmHg). Models were internally loaded with IOP using a fluid cavity, then externally with air puff loading simulated using a turbulent transient computational fluid dynamics model. Corneal dynamic response parameters were extracted and used in the development of two algorithms for IOP and corneal material behavior. The two algorithms were validated against clinical corneal dynamic response parameters for 476 healthy participants. The predictions of IOP and corneal material behavior were tested on how they varied with CCT, R, and age. A biomechanically corrected estimation of intraocular pressure named thereafter as fIOP, and a corneal material stiffness parameter or Stress–Strain Index (fSSI) are presented, both of which showed no significant correlation with R (P-value > .05) and CCT (P-value > .05), where P-value is the statistical significance parameter of the t-test. Further, fIOP had no significant correlation with age (P-value > .05), while fSSI was significantly correlated with age (P = .001), which was found earlier to be strongly correlated with material stiffness.

Item Type:	Book Section
Uncontrolled Keywords:	cornea; corneal material behavior; fluid–structure interaction (FSI); glaucoma; intraocular pressure (IOP); ocular biomechanics
Subjects:	Q Science > Q Science (General) R Medicine > RE Ophthalmology T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Engineering (ENG)
Related URLs:	Publisher
Last Modified:	31 Jan 2023 13:29
URI:	http://gala.gre.ac.uk/id/eprint/38491

Actions (login required)

View Item

Downloads