Polymorphic phase transitions in carbamazepine and 10,11-dihydrocarbamazepine
Clout, Alexander E., Buanz, Asma B. M. ORCID: 0000-0002-2556-1256, Gaisford, Simon and Williams, Gareth R. (2018) Polymorphic phase transitions in carbamazepine and 10,11-dihydrocarbamazepine. Chemistry A European Journal, 24 (51). pp. 13573-13581. ISSN 0947-6539 (Print), 1521-3765 (Online) (doi:https://doi.org/10.1002/chem.201802368)
|
PDF (Open Access Article)
37192 BUANZ_Polymorphic_Phase_Transitions_In_Carbamazepine_And_1011-dihydrocarbamazepine_(OA)_2018.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Temperature-induced phase transitions in carbamazepine (CBZ) and 10,11-dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry–X-ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localised melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 °C, again by a localised intermediate melt phase. CBZ form II converted to form I at 119 °C by a pathway that appears to have included some melting, and form III underwent a part melt-recrystallisation and a part sublimation-recrystallisation to form I.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | hyphenated techniques, pharmaceutical materials, phase transitions, synchrotron X-ray diffraction, thermal analysis |
Subjects: | Q Science > QD Chemistry |
Faculty / School / Research Centre / Research Group: | Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI) |
Last Modified: | 24 Aug 2022 15:37 |
URI: | http://gala.gre.ac.uk/id/eprint/37192 |
Actions (login required)
View Item |
Downloads
Downloads per month over past year